If my muscle could talk: Myokines as a biomarker of frailty

被引：51
作者：
Coelho-Junior, Helio J. [1 ,2 ]
Picca, Anna [1 ,3 ]
Calvani, Riccardo [1 ,3 ]
Uchida, Marco C. [2 ]
Marzetti, Emanuele [3 ]
机构：
[1] Univ Cattolica Sacro Cuore, Rome, Italy
[2] Univ Estadual Campinas, Sch Phys Educ, Appl Kinesiol Lab LCA, Ave Erico Verissimo 701,Cidade Univ Zeferino Vaz, BR-13083851 Campinas, SP, Brazil
[3] Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy
来源：
EXPERIMENTAL GERONTOLOGY | 2019年 / 127卷
关键词：
Sarcopenia; Mobility; Disability; Aging; Exercise; GROWTH-FACTOR-I; SERUM MYOSTATIN LEVELS; HUMAN SKELETAL-MUSCLE; CIRCULATING LEVELS; PHYSICAL FRAILTY; OLDER-PEOPLE; MOLECULAR-MECHANISMS; NEUROTROPHIC FACTOR; UBIQUITIN LIGASES; BIOLOGICAL AGE;
D O I：
10.1016/j.exger.2019.110715
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Frailty is a potentially reversible state of increased vulnerability to negative health-related outcomes that occurs as a result of multisystem biological impairment and environmental aspects. Given the relevance of this condition in both clinics and research, biomarkers of frailty have been actively sought after. Although several candidate biomarkers of frailty have been identified, none of them has yet been incorporated in the assessment or monitoring of the condition. Over the last years, increasing research interest has been focused on myokines, a set of cytokines, small proteins and proteoglycan peptides that are synthetized, expressed and released by skeletal myocytes in response to muscular contractions. Myokines may act in autocrine, paracrine, and endocrine manner and regulate several processes associated with physical frailty, including muscle wasting, dynapenia, and slowness. This review discusses the rationale to support the use of myokines as biomarkers of frailty in older adults.
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页数：9
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