The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies

被引：19

作者：

Liu, Chenxing ^{[1
,2
]}

Kanazawa, Tetsufumi ^{[1
,3
,4
]}

Tian, Ye ^{[1
]}

Saini, Suriati Mohamed ^{[1
,5
]}

Mancuso, Serafino ^{[1
]}

Mostaid, Md Shaki ^{[1
,6
]}

Takahashi, Atsushi ^{[7
,8
]}

Zhang, Dai ^{[9
,10
,11
,12
]}

Zhang, Fuquan ^{[13
]}

Yu, Hao ^{[9
,10
,11
,14
]}

Shin, Hyoung Doo ^{[15
,16
]}

Cheong, Hyun Sub ^{[15
]}

Ikeda, Masashi ^{[17
]}

Kubo, Michiaki ^{[18
]}

Iwata, Nakao ^{[17
]}

Woo, Sung-Il ^{[19
]}

Yue, Weihua ^{[9
,10
,11
]}

Kamatani, Yoichiro ^{[18
,20
]}

Shi, Yongyong ^{[21
]}

Li, Zhiqiang ^{[21
]}

Everall, Ian ^{[22
,23
]}

Pantelis, Christos ^{[1
,4
,24
,25
]}

Bousman, Chad ^{[1
,26
,27
,28
]}

机构：

[1] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Melbourne, Vic, Australia

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA

[3] Osaka Med Coll, Dept Neuropsychiat, Osaka, Japan

[4] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[5] Natl Univ Malaysia, Dept Psychiat, Kuala Lumpur, Malaysia

[6] Brac Univ, Dept Pharm, Dhaka, Bangladesh

[7] RIKEN Ctr Integrat, Lab Stat Anal, Med Sci, Yokohama, Kanagawa, Japan

[8] Natl Cerebral & Cardiovasc Ctr, Lab Omics Informat, Omics Res Ctr, Osaka, Japan

[9] Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China

[10] Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China

[11] Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China

[12] Peking Univ, Peking Tsinghua Joint Ctr Life Sci PKU IDG McGove, Beijing, Peoples R China

[13] Nanjing Med Univ, Affiliated Wuxi Mental Hlth Ctr, Dept Psychiat, Wuxi, Jiangsu, Peoples R China

[14] Jining Med Univ, Dept Psychiat, Jining, Peoples R China

[15] SNP Genet Inc, Dept Genet Epidemiol, Seoul, South Korea

[16] Sogang Univ, Dept Life Sci, Seoul, South Korea

[17] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan

[18] RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

[19] Soon Chun Hyang Univ Hosp, Seoul, South Korea

[20] Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto, Japan

[21] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China

[22] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[23] South London & Maudsley NHS Fdn Trust, London, England

[24] Univ Melbourne, Dept Elect & Elect Engn, Ctr Neural Engn CfNE, Carlton, Vic, Australia

[25] NorthWestern Mental Hlth, Melbourne, Vic, Australia

[26] Univ Calgary, Dept Med Genet, Calgary, AB, Canada

[27] Univ Calgary, Dept Psychiat, Calgary, AB, Canada

[28] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada

来源：

TRANSLATIONAL PSYCHIATRY | 2019年 / 9卷 / 1期

基金：

中国国家自然科学基金; 国家重点研发计划; 澳大利亚国家健康与医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; METAANALYSES;

D O I：

10.1038/s41398-019-0532-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies' findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.

引用

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