Gating of Redox Currents at Gold Nanoelectrodes via DNA Hybridization

被引:46
作者
Liu, Gang [2 ]
Sun, Chunfeng [1 ]
Li, Di [2 ]
Song, Shiping [2 ]
Mao, Bingwei [1 ]
Fan, Chunhai [2 ]
Tian, Zhongqun [1 ]
机构
[1] Xiamen Univ, State Key Lab Phys Chem & Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
[2] Chinese Acad Sci, Phys Biol Lab, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
关键词
SEQUENCE-SPECIFIC DETECTION; ION-CHANNEL SENSORS; FEMTOMOLAR DNA; BASE MISMATCH; ELECTRODES; NANOWIRES;
D O I
10.1002/adma.200903590
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
DNA immobilized at the surface of cone-shaped gold nanoelectrodes provides a favorable platform for artificial ion channels that can gate the redox reaction of ferricyanide. This effect arises from the nanometer-scale curvature and the enhanced mass transfer at nanoelectrodes. The label-free feature based on this ion-channel effect provides a means to develop label-free electrochemical DNA sensors.
引用
收藏
页码:2148 / +
页数:4
相关论文
共 37 条
[1]  
[Anonymous], 2001, ELECTROCHEMICAL METH
[2]  
Aoki H, 2000, ELECTROANAL, V12, P1272, DOI 10.1002/1521-4109(200011)12:16<1272::AID-ELAN1272>3.0.CO
[3]  
2-F
[4]  
Bloomfield V., 2000, NUCL ACIDS STRUCTURE
[5]   The potential and challenges of nanopore sequencing [J].
Branton, Daniel ;
Deamer, David W. ;
Marziali, Andre ;
Bayley, Hagan ;
Benner, Steven A. ;
Butler, Thomas ;
Di Ventra, Massimiliano ;
Garaj, Slaven ;
Hibbs, Andrew ;
Huang, Xiaohua ;
Jovanovich, Stevan B. ;
Krstic, Predrag S. ;
Lindsay, Stuart ;
Ling, Xinsheng Sean ;
Mastrangelo, Carlos H. ;
Meller, Amit ;
Oliver, John S. ;
Pershin, Yuriy V. ;
Ramsey, J. Michael ;
Riehn, Robert ;
Soni, Gautam V. ;
Tabard-Cossa, Vincent ;
Wanunu, Meni ;
Wiggin, Matthew ;
Schloss, Jeffery A. .
NATURE BIOTECHNOLOGY, 2008, 26 (10) :1146-1153
[6]   Curvature Effects in DNA:Au Nanoparticle Conjugates [J].
Cederquist, Kristin B. ;
Keating, Christine D. .
ACS NANO, 2009, 3 (02) :256-260
[7]   A biosensor that uses ion-channel switches [J].
Cornell, BA ;
BraachMaksvytis, VLB ;
King, LG ;
Osman, PDJ ;
Raguse, B ;
Wieczorek, L ;
Pace, RJ .
NATURE, 1997, 387 (6633) :580-583
[8]   Electrical detection of femtomolar DNA via gold-nanoparticle enhancement in carbon-nanotube-network field-effect transistors [J].
Dong, Xiaochen ;
Lau, Ching Man ;
Lohani, Anup ;
Mhaisalkar, Subodh G. ;
Kasim, Johnson ;
Shen, Zexiang ;
Ho, Xinning ;
Rogers, John A. ;
Li, Lain-Jong .
ADVANCED MATERIALS, 2008, 20 (12) :2389-+
[9]   Electrochemical DNA sensors [J].
Drummond, TG ;
Hill, MG ;
Barton, JK .
NATURE BIOTECHNOLOGY, 2003, 21 (10) :1192-1199
[10]   Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA [J].
Fan, CH ;
Plaxco, KW ;
Heeger, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9134-9137