Synthesis, thermal and antitumour studies of Th(IV) complexes with furan-2-carboxaldehyde4-phenyl-3-thiosemicarbazone

被引：16

作者：

Rajendran, Gangadharan ^{[1
]}

Amritha, Chirakuzhi S. ^{[1
]}

Anto, Ruby John ^{[2
]}

Cheriyan, Vino T. ^{[2
]}

机构：

[1] Univ Coll, Dept Chem, Thiruvananthapuram 695034, Kerala, India

[2] Rajiv Gandhi Ctr Biotechnol, Div Canc Res, Thiruvananthapuram 695014, Kerala, India

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2010年 / 75卷 / 06期

关键词：

thorium(IV) complexes; furan-2-carboxaldehyde4-phenyl-3-thiosemicarbazone; antitumour activity; thermal analysis; TRANSITION-METAL COMPLEXES; MIXED-LIGAND COMPLEXES; THIOSEMICARBAZONE COMPLEXES; ANTICANCER ACTIVITY; THORIUM(IV); SEMICARBAZONES; ANTIBACTERIAL; INHIBITION; REDUCTASE; GROWTH;

D O I：

10.2298/JSC090729048R

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thorium(IV) complexes with the Schiff base furan-2-carboxaldehyde4-phenyl-3-thiosemicarbazone (L) were synthesised and characterized. The composition and structure of the metal complexes were proposed based on elemental analysis, molar conductivity measurements, FTIR and H-1-NMR spectroscopy. The Schiff base behaves as a neutral bidentate ligand coordinating through the azomethine N and the thioketo S atoms. From various studies, complexes were ascertained the general formula [ThL2X4] and [ThL2Y2], where X represents NO3-, NCS-, CH3COO-, CH3CHOHCOO-, ClO4- and Y SO42- and C2O42-. The thermal behaviour of the nitrato and oxalato complexes was studied and kinetic and thermodynamic parameters were calculated using the Coats-Redfern Equation. The ligand and a representative complex [ThL2(NO3)(4)] were screened in vitro for their antitumour activity against the human cervical cancer cell line (HeLa).

引用

页码：749 / 761

页数：13

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