Urinary Microbiome: Yin and Yang of the Urinary Tract

被引：108

作者：

Perez-Carrasco, Virginia ^{[1
,2
]}

Soriano-Lerma, Ana ^{[1
,3
]}

Soriano, Miguel ^{[1
,4
]}

Gutierrez-Fernandez, Jose ^{[2
]}

Garcia-Salcedo, Jose A. ^{[1
,2
]}

机构：

[1] Univ Granada, Pfizer, Ctr Genom & Oncol Res, GENYO, Granada, Spain

[2] Univ Hosp Virgen Nieves, Biosanitary Res Inst IBS Granada, Microbiol Unit, Granada, Spain

[3] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Fac Pharm, Dept Physiol, Granada, Spain

[4] Univ Almeria, Ctr Intens Mediterranean Agrosyst & Agrifood Biot, Almeria, Spain

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 11卷

关键词：

microbiome; urinary tract; infection; disease; health; sequencing; PELVIC PAIN SYNDROME; GUT MICROBIOTA; ESCHERICHIA-COLI; METHANOBREVIBACTER-SMITHII; NEUROPATHIC BLADDER; HEALTHY URINE; WOMEN; INFECTIONS; INCONTINENCE; BACTERIA;

D O I：

10.3389/fcimb.2021.617002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.

引用

页数：17

共 144 条

[61] The microbiome and host mucosal interactions in urinary tract diseases [J].

Jones-Freeman, Bernadette ;

Chonwerawong, Michelle ;

Marcelino, Vanessa R. ;

Deshpande, Aniruddh, V ;

Forster, Samuel C. ;

Starkey, Malcolm R. .

MUCOSAL IMMUNOLOGY, 2021, 14 (04) :779-792

[62] Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics [J].

Jovel, Juan ;

Patterson, Jordan ;

Wang, Weiwei ;

Hotte, Naomi ;

O'Keefe, Sandra ;

Mitchel, Troy ;

Perry, Troy ;

Kao, Dina ;

Mason, Andrew L. ;

Madsen, Karen L. ;

Wong, Gane K-S .

FRONTIERS IN MICROBIOLOGY, 2016, 7

[63] Benchmarking urine storage and collection conditions for evaluating the female urinary microbiome [J].

Jung, Carrie E. ;

Chopyk, Jessica ;

Shin, Ji Hyun ;

Lukacz, Emily S. ;

Brubaker, Linda ;

Schwanemann, Leila K. ;

Knight, Rob ;

Wolfe, Alan J. ;

Pride, David T. .

SCIENTIFIC REPORTS, 2019, 9 (1)

[64] Community profiling of the urinary microbiota: considerations for low-biomass samples [J].

Karstens, Lisa ;

Asquith, Mark ;

Caruso, Vincent ;

Rosenbaum, James T. ;

Fair, Damien A. ;

Braun, Jonathan ;

Gregory, W. Thomas ;

Nardos, Rahel ;

McWeeney, Shannon K. .

NATURE REVIEWS UROLOGY, 2018, 15 (12) :735-749

[65] Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity? [J].

Karstens, Lisa ;

Asquith, Mark ;

Davin, Sean ;

Stauffer, Patrick ;

Fair, Damien ;

Gregory, W. Thomas ;

Rosenbaum, James T. ;

McWeeney, Shannon K. ;

Nardos, Rahel .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2016, 6

[66] Probiotics in human gut microbiota can degrade host glycosaminoglycans [J].

Kawai, Keigo ;

Kamochi, Reiko ;

Oiki, Sayoko ;

Murata, Kousaku ;

Hashimoto, Wataru .

SCIENTIFIC REPORTS, 2018, 8

[67] Enterococcal Metabolite Cues Facilitate Interspecies Niche Modulation and Polymicrobial Infection [J].

Keogh, Damien ;

Tay, Wei Hong ;

Ho, Yao Yong ;

Dale, Jennifer L. ;

Chen, Siyi ;

Umashankar, Shivshankar ;

Williams, Rohan B. H. ;

Chen, Swaine L. ;

Dunny, Gary M. ;

Kline, Kimberly A. .

CELL HOST & MICROBE, 2016, 20 (04) :493-503

[68] Spectrum of Bacterial Colonization Associated with Urothelial Cells from Patients with Chronic Lower Urinary Tract Symptoms [J].

Khasriya, Rajvinder ;

Sathiananthamoorthy, Sanchutha ;

Ismail, Salim ;

Kelsey, Michael ;

Wilson, Mike ;

Rohn, Jennifer L. ;

Malone-Lee, James .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (07) :2054-2062

[69] Human Urine Is Not Sterile - Shift of Paradigm [J].

Kogan, Michael I. ;

Naboka, Yulia L. ;

Ibishev, Khalid S. ;

Gudima, Irina A. ;

Naber, Kurt G. .

UROLOGIA INTERNATIONALIS, 2015, 94 (04) :445-452

[70] Defining the relationship between vaginal and urinary microbiomes [J].

Komesu, Yuko M. ;

Dinwiddie, Darrell L. ;

Richter, Holly E. ;

Lukacz, Emily S. ;

Sung, Vivian W. ;

Siddiqui, Nazema Y. ;

Zyczynski, Halina M. ;

Ridgeway, Beri ;

Rogers, Rebecca G. ;

Arya, Lily A. ;

Mazloomdoost, Donna ;

Levy, Josh ;

Carper, Benjamin ;

Gantz, Marie G. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2020, 222 (02)

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