Cancer immunotherapy targeting neoantigens

被引：168

作者：

Lu, Yong-Chen ^{[1
]}

Robbins, Paul F. ^{[1
]}

机构：

[1] NCI, Surg Branch, NIH, Bldg 10-CRC,Rm 3W-3864,10 Ctr Dr,MSC 1201, Bethesda, MD 20892 USA

来源：

SEMINARS IN IMMUNOLOGY | 2016年 / 28卷 / 01期

关键词：

Cancer immunotherapy; Tumor immunology; Neoantigen; Mutation; CYTOLYTIC T-LYMPHOCYTES; RENAL-CELL CARCINOMA; COMPLETE TUMOR-REGRESSION; POINT MUTATION; HUMAN-MELANOMA; METASTATIC MELANOMA; LUNG-CARCINOMA; ANTI-PD-L1; ANTIBODY; CTLA-4; BLOCKADE; HIGH-FREQUENCY;

D O I：

10.1016/j.smim.2015.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens. Published by Elsevier Ltd

引用

页码：22 / 27

页数：6

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