IGF-I and osteoporosis

被引:1
作者
Rosen, CJ [1 ]
机构
[1] Univ Maine, St Joseph Hosp, Maine Ctr Osteoporosis Res & Educ, Bangor, ME 04401 USA
关键词
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
This article discusses the clinical use of insulin-like growth factors (IGF) as a potential diagnostic tool for osteoporosis. Although there is a numerical relationship between measurable IGF-I and bone mass, or risk of fractures, it is not clear that it is causal. Caution must be undertaken in deciphering the results of a low, normal, or high IGF-I in relation to osteoporosis. Further studies should help define more clearly the possible pathogenic relationship between IGF-I and bone mass.
引用
收藏
页码:591 / +
页数:13
相关论文
共 82 条
  • [61] Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions
    Rajaram, S
    Baylink, DJ
    Mohan, S
    [J]. ENDOCRINE REVIEWS, 1997, 18 (06) : 801 - 831
  • [62] INSULIN-LIKE GROWTH-FACTOR-I AND GROWTH-FACTOR-II IN HEALTHY WOMEN WITH AND WITHOUT ESTABLISHED OSTEOPOROSIS
    RAVN, P
    OVERGAARD, K
    SPENCER, EM
    CHRISTIANSEN, C
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 132 (03) : 313 - 319
  • [63] REED BY, 1995, J BONE MINER RES, V10, P1218
  • [64] Growth hormone insulin-like growth factor-I axis in aging: A summary of a National Institutes of Aging sponsored symposium
    Rosen, CJ
    Conover, C
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (12) : 3919 - 3922
  • [65] Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: Implications for genetic studies of bone mineral density
    Rosen, CJ
    Kurland, ES
    Vereault, D
    Adler, RA
    Rackoff, PJ
    Craig, WY
    Witte, S
    Rogers, J
    Bilezikian, JP
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (07) : 2286 - 2290
  • [66] Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities
    Rosen, CJ
    Dimai, HP
    Vereault, D
    Donahue, LR
    Beamer, WG
    Farley, J
    Linkhart, S
    Linkhart, T
    Mohan, S
    Baylink, DJ
    [J]. BONE, 1997, 21 (03) : 217 - 223
  • [67] ROSEN CJ, 1994, P SOC EXP BIOL MED, V206, P83
  • [68] Effects of age and estrogen status on the skeletal IGF regulatory system - Studies with human marrow
    Rosen, CJ
    Verault, D
    Steffens, C
    Cheleuitte, D
    Glowacki, J
    [J]. ENDOCRINE, 1997, 7 (01) : 77 - 80
  • [69] EFFECTS OF HUMAN GROWTH-HORMONE IN MEN OVER 60 YEARS OLD
    RUDMAN, D
    FELLER, AG
    NAGRAJ, HS
    GERGANS, GA
    LALITHA, PY
    GOLDBERG, AF
    SCHLENKER, RA
    COHN, L
    RUDMAN, IW
    MATTSON, DE
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (01) : 1 - 6
  • [70] SALMON WD, 1957, J LAB CLIN MED, V49, P825