IGF-I and osteoporosis

被引:0
作者
Rosen, CJ [1 ]
机构
[1] Univ Maine, St Joseph Hosp, Maine Ctr Osteoporosis Res & Educ, Bangor, ME 04401 USA
关键词
D O I
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中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
This article discusses the clinical use of insulin-like growth factors (IGF) as a potential diagnostic tool for osteoporosis. Although there is a numerical relationship between measurable IGF-I and bone mass, or risk of fractures, it is not clear that it is causal. Caution must be undertaken in deciphering the results of a low, normal, or high IGF-I in relation to osteoporosis. Further studies should help define more clearly the possible pathogenic relationship between IGF-I and bone mass.
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页码:591 / +
页数:13
相关论文
共 82 条
[61]   Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions [J].
Rajaram, S ;
Baylink, DJ ;
Mohan, S .
ENDOCRINE REVIEWS, 1997, 18 (06) :801-831
[62]   INSULIN-LIKE GROWTH-FACTOR-I AND GROWTH-FACTOR-II IN HEALTHY WOMEN WITH AND WITHOUT ESTABLISHED OSTEOPOROSIS [J].
RAVN, P ;
OVERGAARD, K ;
SPENCER, EM ;
CHRISTIANSEN, C .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 132 (03) :313-319
[63]  
REED BY, 1995, J BONE MINER RES, V10, P1218
[64]   Growth hormone insulin-like growth factor-I axis in aging: A summary of a National Institutes of Aging sponsored symposium [J].
Rosen, CJ ;
Conover, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (12) :3919-3922
[65]   Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: Implications for genetic studies of bone mineral density [J].
Rosen, CJ ;
Kurland, ES ;
Vereault, D ;
Adler, RA ;
Rackoff, PJ ;
Craig, WY ;
Witte, S ;
Rogers, J ;
Bilezikian, JP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (07) :2286-2290
[66]   Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities [J].
Rosen, CJ ;
Dimai, HP ;
Vereault, D ;
Donahue, LR ;
Beamer, WG ;
Farley, J ;
Linkhart, S ;
Linkhart, T ;
Mohan, S ;
Baylink, DJ .
BONE, 1997, 21 (03) :217-223
[67]  
ROSEN CJ, 1994, P SOC EXP BIOL MED, V206, P83
[68]   Effects of age and estrogen status on the skeletal IGF regulatory system - Studies with human marrow [J].
Rosen, CJ ;
Verault, D ;
Steffens, C ;
Cheleuitte, D ;
Glowacki, J .
ENDOCRINE, 1997, 7 (01) :77-80
[69]   EFFECTS OF HUMAN GROWTH-HORMONE IN MEN OVER 60 YEARS OLD [J].
RUDMAN, D ;
FELLER, AG ;
NAGRAJ, HS ;
GERGANS, GA ;
LALITHA, PY ;
GOLDBERG, AF ;
SCHLENKER, RA ;
COHN, L ;
RUDMAN, IW ;
MATTSON, DE .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (01) :1-6
[70]  
SALMON WD, 1957, J LAB CLIN MED, V49, P825