IGF-I and osteoporosis

被引：1
作者：
Rosen, CJ [1 ]
机构：
[1] Univ Maine, St Joseph Hosp, Maine Ctr Osteoporosis Res & Educ, Bangor, ME 04401 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2000年 / 20卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
This article discusses the clinical use of insulin-like growth factors (IGF) as a potential diagnostic tool for osteoporosis. Although there is a numerical relationship between measurable IGF-I and bone mass, or risk of fractures, it is not clear that it is causal. Caution must be undertaken in deciphering the results of a low, normal, or high IGF-I in relation to osteoporosis. Further studies should help define more clearly the possible pathogenic relationship between IGF-I and bone mass.
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页码：591 / +
页数：13
相关论文
共 82 条
  • [31] TESTOSTERONE ADMINISTRATION INCREASES INSULIN-LIKE GROWTH FACTOR-I LEVELS IN NORMAL MEN
    HOBBS, CJ
    PLYMATE, SR
    ROSEN, CJ
    ADLER, RA
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (03) : 776 - 779
  • [32] Functional consequences of the somatopause and its treatment
    Hoffman, AR
    Lieberman, SA
    Butterfield, G
    Thompson, J
    Hintz, RL
    Ceda, GP
    Marcus, R
    [J]. ENDOCRINE, 1997, 7 (01) : 73 - 76
  • [33] EXTRACELLULAR-MATRIX CONTAINS INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-5 - POTENTIATION OF THE EFFECTS OF IGF-I
    JONES, JI
    GOCKERMAN, A
    BUSBY, WH
    CAMACHOHUBNER, C
    CLEMMONS, DR
    [J]. JOURNAL OF CELL BIOLOGY, 1993, 121 (03) : 679 - 687
  • [34] INSULIN-LIKE GROWTH-FACTORS AND THEIR BINDING-PROTEINS - BIOLOGICAL ACTIONS
    JONES, JI
    CLEMMONS, DR
    [J]. ENDOCRINE REVIEWS, 1995, 16 (01) : 3 - 34
  • [35] EVIDENCE THAT HUMAN BONE-CELLS IN CULTURE PRODUCE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-4 AND PROTEIN-5 PROTEASES
    KANZAKI, S
    HILLIKER, S
    BAYLINK, DJ
    MOHAN, S
    [J]. ENDOCRINOLOGY, 1994, 134 (01) : 383 - 392
  • [36] INSULIN-LIKE GROWTH FACTOR-I COMPARISONS IN HEALTHY TWIN CHILDREN
    KAO, PC
    MATHENY, AP
    LANG, CA
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (02) : 310 - 312
  • [37] KOPERAK C, 1990, J CLIN ENDOCR METAB, V71, P329
  • [38] KURLAND E, 1998, HERITABILITY SERUM I
  • [39] Insulin-like growth factor-I in men with idiopathic osteoporosis
    Kurland, ES
    Rosen, CJ
    Cosman, F
    McMahon, D
    Chan, F
    Shane, E
    Lindsay, R
    Dempster, D
    Bilezikian, JP
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (09) : 2799 - 2805
  • [40] KURLAND ES, 1996, J BONE MINER RES, V11, pS1323
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