Poly Cystic Ovarian Syndrome: An Updated Overview

被引:165
作者
El Hayek, Samer [1 ]
Bitar, Lynn [1 ]
Hamdar, Layal H. [1 ]
Mirza, Fadi G. [2 ,3 ]
Daoud, Georges [1 ]
机构
[1] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon
[2] Amer Univ Beirut, Fac Med, Dept Obstet & Gynecol, Beirut, Lebanon
[3] Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA
关键词
PCOS; ovary; insulin; obesity; diabetes; IMPAIRED GLUCOSE-TOLERANCE; QUALITY-OF-LIFE; INSULIN SENSITIZER PIOGLITAZONE; REGULAR MENSTRUAL CYCLES; OMENTAL ADIPOSE-TISSUE; IN-VITRO FERTILIZATION; D-CHIRO-INOSITOL; POLYCYSTIC-OVARY; SYNDROME PCOS; METABOLIC SYNDROME;
D O I
10.3389/fphys.2016.00124
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease (CVD), infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS. It will also present a general overview about the morbidities associated with this disease, specifically with its more severe classic form. Finally, the review will stress on the various aspects of treatment and screening recommendations currently used in the management of this condition.
引用
收藏
页数:15
相关论文
共 186 条
[111]   Detecting insulin resistance in polycystic ovary syndrome: Purposes and pitfalls [J].
Legro, RS ;
Castracane, VD ;
Kauffman, RP .
OBSTETRICAL & GYNECOLOGICAL SURVEY, 2004, 59 (02) :141-154
[112]   Polycystic ovary syndrome and cardiovascular disease: A premature association? [J].
Legro, RS .
ENDOCRINE REVIEWS, 2003, 24 (03) :302-312
[113]   Assessment of glucose metabolism in polycystic ovary syndrome: HbA1c or fasting glucose compared with the oral glucose tolerance test as a screening method [J].
Lerchbaum, E. ;
Schwetz, V. ;
Giuliani, A. ;
Obermayer-Pietsch, B. .
HUMAN REPRODUCTION, 2013, 28 (09) :2537-2544
[114]   Pioglitazone and bladder cancer risk: a multipopulation pooled, cumulative exposure analysis [J].
Levin, Daniel ;
Bell, Samira ;
Sund, Reijo ;
Hartikainen, Sirpa A. ;
Tuomilehto, Jaakko ;
Pukkala, Eero ;
Keskimaki, Ilmo ;
Badrick, Ellena ;
Renehan, Andrew G. ;
Buchan, Iain E. ;
Bowker, Samantha L. ;
Minhas-Sandhu, Jasjeet K. ;
Zafari, Zafar ;
Marra, Carlo ;
Johnson, Jeffrey A. ;
Stricker, Bruno H. ;
Uitterlinden, Andre G. ;
Hofman, Albert ;
Ruiter, Rikje ;
de Keyser, Catherine E. ;
MacDonald, Thomas M. ;
Wild, Sarah H. ;
McKeigue, Paul M. ;
Colhoun, Helen M. .
DIABETOLOGIA, 2015, 58 (03) :493-504
[115]   Polycystic ovary syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from a meta-analysis [J].
Li, Yanan ;
Li, Yan ;
Ng, Ernest Hung Yu ;
Stener-Victorin, Elisabet ;
Hou, Lihui ;
Wu, Taixiang ;
Han, Fengjuan ;
Wu, Xiaoke .
FERTILITY AND STERILITY, 2011, 96 (02) :452-458
[116]  
Lidegaard O, 2012, NEW ENGL J MED, V366, P2257, DOI 10.1056/NEJMoa1111840
[117]   Insulin Resistance Is a Sufficient Basis for Hyperandrogenism in Lipodystrophic Women with Polycystic Ovarian Syndrome [J].
Lungu, Andreea O. ;
Zadeh, Elika Safar ;
Goodling, Anne ;
Cochran, Elaine ;
Gorden, Phillip .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (02) :563-567
[118]   Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS:: a randomized placebo-controlled study [J].
Majuri, A. ;
Santaniemi, M. ;
Rautio, K. ;
Kunnari, A. ;
Vartiainen, J. ;
Ruokonen, A. ;
Kesaniemi, Y. A. ;
Tapanainen, J. S. ;
Ukkola, O. ;
Morin-Papunen, L. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2007, 156 (02) :263-269
[119]   High prevalence of polycystic ovary syndrome in women born small for gestational age [J].
Melo, A. S. ;
Vieira, C. S. ;
Barbieri, M. A. ;
Rosa-e-Silva, A. C. J. S. ;
Silva, A. A. M. ;
Cardoso, V. C. ;
Reis, R. M. ;
Ferriani, R. A. ;
Silva-de-Sa, M. F. ;
Bettiol, H. .
HUMAN REPRODUCTION, 2010, 25 (08) :2124-2131
[120]   Hormonal contraceptive choice for women with PCOS: a systematic review of randomized trials and observational studies [J].
Mendoza, Nicolas ;
Simoncini, Tommaso ;
Genazzani, Alessandro D. .
GYNECOLOGICAL ENDOCRINOLOGY, 2014, 30 (12) :850-860