Poly Cystic Ovarian Syndrome: An Updated Overview

被引:165
作者
El Hayek, Samer [1 ]
Bitar, Lynn [1 ]
Hamdar, Layal H. [1 ]
Mirza, Fadi G. [2 ,3 ]
Daoud, Georges [1 ]
机构
[1] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon
[2] Amer Univ Beirut, Fac Med, Dept Obstet & Gynecol, Beirut, Lebanon
[3] Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA
关键词
PCOS; ovary; insulin; obesity; diabetes; IMPAIRED GLUCOSE-TOLERANCE; QUALITY-OF-LIFE; INSULIN SENSITIZER PIOGLITAZONE; REGULAR MENSTRUAL CYCLES; OMENTAL ADIPOSE-TISSUE; IN-VITRO FERTILIZATION; D-CHIRO-INOSITOL; POLYCYSTIC-OVARY; SYNDROME PCOS; METABOLIC SYNDROME;
D O I
10.3389/fphys.2016.00124
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease (CVD), infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS. It will also present a general overview about the morbidities associated with this disease, specifically with its more severe classic form. Finally, the review will stress on the various aspects of treatment and screening recommendations currently used in the management of this condition.
引用
收藏
页数:15
相关论文
共 186 条
[1]   Can metformin reduce insulin resistance in polycystic ovary syndrome? [J].
Acbay, O ;
Gundogdu, S .
FERTILITY AND STERILITY, 1996, 65 (05) :946-949
[2]   Infants of Women with Polycystic Ovary Syndrome Have Lower Cord Blood Androstenedione and Estradiol Levels [J].
Anderson, Helen ;
Fogel, Naomi ;
Grebe, Stefan K. ;
Singh, Ravinder J. ;
Taylor, Robert L. ;
Dunaif, Andrea .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (05) :2180-2186
[3]  
[Anonymous], 2001, CA-CANCER J CLIN
[4]  
[Anonymous], AM J OBSTET GYNECOL, DOI DOI 10.1016/J.AJ0G.2010.03.008
[5]   Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: Amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance [J].
Arslanian, SA ;
Lewy, V ;
Danadian, K ;
Saad, R .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (04) :1555-1559
[6]   Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span [J].
Azziz, R ;
Marin, C ;
Hoq, L ;
Badamgarav, E ;
Song, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (08) :4650-4658
[7]   The prevalence and features of the polycystic ovary syndrome in an unselected population [J].
Azziz, R ;
Woods, KS ;
Reyna, R ;
Key, TJ ;
Knochenhauer, ES ;
Yildiz, BO .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2745-2749
[8]   Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An Androgen Excess Society guideline [J].
Azziz, Ricardo ;
Carmina, Enrico ;
Dewailly, Didier ;
Diamanti-Kandarakis, Evanthia ;
Escobar-Morreale, Hector F. ;
Futterweit, Walter ;
Janssen, Onno E. ;
Legro, Richard S. ;
Norman, Robert J. ;
Taylor, Ann E. ;
Witchel, Selma F. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (11) :4237-4245
[9]   The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report [J].
Azziz, Ricardo ;
Carmina, Enrico ;
Dewailly, Didier ;
Diamanti-Kandarakis, Evanthia ;
Escobar-Morreale, Hector F. ;
Futterweit, Walter ;
Janssen, Onno E. ;
Legro, Richard S. ;
Norman, Robert J. ;
Taylor, Ann E. ;
Witchel, Selina F. .
FERTILITY AND STERILITY, 2009, 91 (02) :456-488
[10]   Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance [J].
Bahceci, M ;
Tuzcu, A ;
Canoruc, N ;
Tuzun, Y ;
Kidir, V ;
Aslan, C .
HORMONE RESEARCH, 2004, 62 (06) :283-287