Advances in in vivo imagring of serotonergic neurons in neuropsychiatric disorders

被引：46
作者：
Hesse, S [1 ]
Barthel, H
Schwarz, J
Sabri, O
Müller, U
机构：
[1] Univ Leipzig, Univ Hosp, Dept Nucl Med, Leipzig, Germany
[2] Univ Leipzig, Univ Hosp, Dept Neurol, Leipzig, Germany
[3] Univ Cambridge, Dept Expt Psychol, Cambridge, England
[4] Univ Cambridge, Dept Psychiat, Cambridge, England
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2004年 / 28卷 / 06期
关键词：
serotonin transporter; SPECT; PET;
D O I：
10.1016/j.neubiorev.2004.08.004
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Alterations of central serotonergic neurotransmission, particularly changes in the presynaptically located serotonin transporter (SERT) availability, are thought to be one of the major pathomechanisms of neuropsychiatric symptoms. Modem neuroimaging techniques such as single-photon emission computed tomography and positron emission tomography employ radiolabeled tracers, which bind to SERT, and thus, allow detection of cerebral SERT availability in vivo. We review SERT imaging studies in patients with depression, anxiety disorders, eating disorders and patients with neurological diseases. We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：547 / 563
页数：17
相关论文
共 140 条
  • [1] Acton PD, 2001, J NUCL MED, V42, P1556
  • [2] ALLAIN H, 2003, HUM PSYCHOPHARM CLIN, V18, P251
  • [3] Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-lA receptors in the human brain
    Andrée, B
    Hedman, A
    Thorberg, SO
    Nilsson, D
    Halldin, C
    Farde, L
    [J]. PSYCHOPHARMACOLOGY, 2003, 167 (01) : 37 - 45
  • [4] Genetics of the serotonergic system in suicidal behavior
    Arango, V
    Huang, YY
    Underwood, MD
    Mann, JJ
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 2003, 37 (05) : 375 - 386
  • [5] Audenaert K, 2003, J NUCL MED, V44, P163
  • [6] Barthel H, 2004, J NUCL MED, V45, P923
  • [7] Tryptophan depletion and its implications for psychiatry
    Bell, C
    Abrams, J
    Nutt, D
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 2001, 178 : 399 - 405
  • [8] Berding G, 2003, NUKLEARMED-NUCL MED, V42, P31
  • [9] Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [C-11]WAY-100635
    Bhagwagar, Z
    Montgomery, AJ
    Grasby, PM
    Cowen, PJ
    [J]. BIOLOGICAL PSYCHIATRY, 2003, 54 (09) : 890 - 895
  • [10] Monoamine depletion in psychiatric and healthy populations: review
    Booij, L
    Van der Does, AJW
    Riedel, WJ
    [J]. MOLECULAR PSYCHIATRY, 2003, 8 (12) : 951 - 973
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