The genomics of insecticide resistance: insights from recent studies in African malaria vectors

被引：13
作者：
Clarkson, Chris S. [1 ]
Temple, Helen J. [2 ]
Miles, Alistair [3 ]
机构：
[1] Wellcome Sanger Inst, Hinxton CB10 1SA, England
[2] Biodivers Consultancy Ltd, Cambridge CB2 1SJ, England
[3] Big Data Inst, Oxford OX3 7FZ, England
来源：
CURRENT OPINION IN INSECT SCIENCE | 2018年 / 27卷
关键词：
GATED SODIUM-CHANNEL; ANOPHELES-GAMBIAE; PYRETHROID RESISTANCE; PLASMODIUM-FALCIPARUM; MUTATION; GENE; IDENTIFICATION; MOSQUITOS; SELECTION; MARKERS;
D O I：
10.1016/j.cois.2018.05.017
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Over 80% of the world's population is at risk from arthropod-vectored diseases, and arthropod crop pests are a significant threat to food security. Insecticides are our front-line response for controlling these disease vectors and pests, and consequently the increasing prevalence of insecticide resistance is of global concern. Here we provide a brief overview of how genomics can be used to implement effective insecticide resistance management (IRM), with a focus on recent advances in the study of Anopheles gambiae, the major vector of malaria in Africa. These advances unlock the potential for a predictive form of IRM, allowing tractable feedback for stakeholders, where the latest field data and well parameterised models can maximise the lifetime and effectiveness of available insecticides.
引用
收藏
页码：111 / 115
页数：5
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