Emerging role of interleukin-13 in cardiovascular diseases: A ray of hope

被引：10

作者：

Qian, Ningjing ^{[1
,2
]}

Gao, Ying ^{[1
,2
]}

Wang, Jian'an ^{[1
,2
]}

Wang, Yaping ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, 88 Jiefang Rd, Hangzhou 310009, Peoples R China

[2] Cardiovasc Key Lab Zhejiang Prov, Hangzhou, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021年 / 25卷 / 12期

基金：

中国国家自然科学基金;

关键词：

cardiovascular diseases; immunotherapy; inflammation; interleukin‐ 13; VIRAL MYOCARDITIS; CARDIAC INJURY; HEART; INFLAMMATION; FIBROSIS; RECEPTOR; MACROPHAGES; DYSFUNCTION; TISSUE;

D O I：

10.1111/jcmm.16566

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite the great progress made in the treatment for cardiovascular diseases (CVDs), the morbidity and mortality of CVDs remains high due to the lack of effective treatment strategy. Inflammation is a central pathophysiological feature of the heart in response to both acute and chronic injury, while the molecular basis and underlying mechanisms remains obscure. Interleukin (IL)-13, a pro-inflammatory cytokine, has been known as a critical mediator in allergy and asthma. Recent studies appraise the role of IL-13 in CVDs, revealing that IL-13 is not only involved in more obvious cardiac inflammatory diseases such as myocarditis but also relevant to acute or chronic CVDs of other origins, such as myocardial infarction and heart failure. The goal of this review is to summarize the advancement in our knowledge of the regulations and functions of IL-13 in CVDs and to discuss the possible mechanisms of IL-13 involved in CVDs. We highlight that IL-13 may be a promising target for immunotherapy in CVDs.

引用

页码：5351 / 5357

页数：7

共 59 条

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