Remyelination in multiple sclerosis

被引：140
作者：
Brück, W [1 ]
Kuhlmann, T [1 ]
Stadelmann, C [1 ]
机构：
[1] Humboldt Univ, Charite, Inst Neuropathol, D-13353 Berlin, Germany
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2003年 / 206卷 / 02期
关键词：
multiple sclerosis; remyelination; oligodendrocytes; MRI;
D O I：
10.1016/s0022-510x(02)00191-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined. The present review will focus on the morphological appearance of remyelinating MS lesions, their correlation with oligodendrocyte pathology, and possible markers for remyelination in imaging. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：181 / 185
页数：5
相关论文
共 60 条
[1]  
ALLEN IV, 1991, MCALPINES MULTIPLE S, V2, P341
[2]   A unique population of circulating autoantibodies promotes central nervous system remyelination [J].
Asakura, K ;
Rodriguez, M .
MULTIPLE SCLEROSIS, 1998, 4 (03) :217-221
[3]   Imaging of remyelination [J].
Barkhof, F .
MULTIPLE SCLEROSIS, 1997, 3 (02) :129-132
[4]  
Bitsch A, 1999, AM J NEURORADIOL, V20, P1619
[5]   A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions [J].
Bitsch, A ;
Kuhlmann, T ;
Stadelmann, C ;
Lassmann, H ;
Lucchinetti, C ;
Brück, W .
ANNALS OF NEUROLOGY, 2001, 49 (06) :793-796
[6]   Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS [J].
Blakemore, WF ;
Chari, DM ;
Gilson, JM ;
Crang, AJ .
GLIA, 2002, 38 (02) :155-168
[7]   MONOCYTE-MACROPHAGE DIFFERENTIATION IN EARLY MULTIPLE-SCLEROSIS LESIONS [J].
BRUCK, W ;
PORADA, P ;
POSER, S ;
RIECKMANN, P ;
HANEFELD, F ;
KRETZSCHMAR, HA ;
LASSMANN, H .
ANNALS OF NEUROLOGY, 1995, 38 (05) :788-796
[8]   OLIGODENDROCYTES IN THE EARLY COURSE OF MULTIPLE-SCLEROSIS [J].
BRUCK, W ;
SCHMIED, M ;
SUCHANEK, G ;
BRUCK, Y ;
BREITSCHOPF, H ;
POSER, S ;
PIDDLESDEN, S ;
LASSMANN, H .
ANNALS OF NEUROLOGY, 1994, 35 (01) :65-73
[9]   Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination -: possible markers for an antibody-mediated process [J].
Brück, W ;
Neubert, K ;
Berger, T ;
Weber, JR .
MULTIPLE SCLEROSIS JOURNAL, 2001, 7 (03) :173-177
[10]   Embryonic stem cell-derived glial precursors:: A source of myelinating transplants [J].
Brüstle, O ;
Jones, KN ;
Learish, RD ;
Karram, K ;
Choudhary, K ;
Wiestler, OD ;
Duncan, ID ;
McKay, RDG .
SCIENCE, 1999, 285 (5428) :754-756
123456