Role of Probiotics in Crohn's Disease and in Pouchitis

被引:0
作者
Guslandi, Mario [1 ]
机构
[1] S Raffaele Univ Hosp, Div Gastroenterol & Digest Endoscopy, Clin Hepatogastroenterol Unit, Milan, Italy
关键词
Crohn's disease; pouchitis; probiotics; DOUBLE-BLIND; SACCHAROMYCES-BOULARDII; ANAL-ANASTOMOSIS; ULCERATIVE-COLITIS; POSTOPERATIVE RECURRENCE; LACTOBACILLUS-JOHNSONII; MAINTAINING REMISSION; MAINTENANCE TREATMENT; FECAL MICROBIOTA; CLINICAL-TRIAL;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The alterations in the gut microbiota observed in patients with inflammatory bowel disease and in particular in Crohn's disease and in ulcerative colitis patients with pouchitis, provide the rationale for administering probiotic agents in the medical treatment of those conditions. In the maintenance treatment of inactive Crohn's disease probiotics, when administered alone, were found ineffective in preventing clinical and/or endoscopic recurrence. By contrast, a combination of a probiotic agent (eg, Saccharomyces boulardii) with standard pharmacological therapy can promote clinical benefit. In patients with pouchitis, so far only the probiotic mixture VSL #3 proved to effectively prevent relapses after successful antibiotic treatment of active inflammation. Further controlled studies, enrolling higher numbers of patients, are needed to better identify the exact role of probiotics in this area.
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收藏
页码:S46 / S49
页数:4
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