Galectin-7 in lymphoma:: Elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model

被引:44
作者
Demers, Melanie
Biron-Pain, Katherine
Hebert, Josee
Lamarre, Alain
Magnaldo, Thierry
St-Pierre, Yves
机构
[1] Univ Quebec, Inst Armand Frappier, INRS, Laval, PQ H7V 1B7, Canada
[2] Hop Maison Neuve Rosemont, Ctr Rech Guy Bernier, Banque Cellules Leucem Quebec, Montreal, PQ H1T 2M4, Canada
[3] Inst Gustave Roussy, UPR 2169, CNRS, Villejuif, France
关键词
D O I
10.1158/0008-5472.CAN-06-3891
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Galectin-7 is found mainly in stratified squamous epithelia as well as in various other types of cancer cells. As with other members of the galectin family, the expression of galectin-7 has been shown to negatively regulate the development of some tumors while correlating with the progression of other tumor types. For example, up-regulation of galectin-7 is associated with rat mammary carcinomas and with progression to T-cell malignancy. Here, we provide evidence indicating that galectin-7 functions as an important molecule in the dissemination of lymphoma cells in vivo. We found that stable transfection of lymphoma cells with a plasmid encoding antisense galectin-7 cDNA significantly inhibited the dissemination and invasion of lymphoma cells to peripheral organs, thereby increasing the survival of mice. We also found that inhibition of galectin-7 in aggressive lymphoma cells correlated with a decreased invasion of tumor cells in target organs and a reduced expression of matrix metalloproteinase-9, a gene associated with a poor prognosis in non-Hodgkin's lymphoma. We finally examined the expression of galectin-7 in 50 specimens of different mature B-cell neoplasms and found high galectin-7 expression levels in a significant proportion of mature B-cell neoplasms but not in normal B cells. Taken together, these findings suggest that galectin-7 is a potential therapeutic target in the treatment of lymphoid malignancies.
引用
收藏
页码:2824 / 2829
页数:6
相关论文
共 34 条
[1]  
Allione A, 1998, J IMMUNOL, V161, P2114
[2]   Molecular modeling and mutagenesis studies of the N-terminal domains of galectin-3: evidence for participation with the C-terminal carbohydrate recognition domain in oligosaccharide binding [J].
Barboni, EAM ;
Bawumia, S ;
Henrick, K ;
Hughes, RC .
GLYCOBIOLOGY, 2000, 10 (11) :1201-1208
[3]  
BARONDES SH, 1994, J BIOL CHEM, V269, P20807
[4]   Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes [J].
Bernerd, F ;
Sarasin, A ;
Magnaldo, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11329-11334
[5]   Galectin-1 induces partial TCR ζ-chain phosphorylation and antagonizes processive TCR signal transduction [J].
Chung, CD ;
Patel, VP ;
Moran, M ;
Lewis, LA ;
Miceli, MC .
JOURNAL OF IMMUNOLOGY, 2000, 165 (07) :3722-3729
[6]   Sweet 'n' sour: the impact of differential glycosylation on T cell responses [J].
Daniels, MA ;
Hogquist, KA ;
Jameson, SC .
NATURE IMMUNOLOGY, 2002, 3 (10) :903-910
[7]   A novel function for galectin-7:: Promoting tumorigenesis by up-regulating MMP-9 gene expression [J].
Demers, M ;
Magnaldo, T ;
St-Pierre, Y .
CANCER RESEARCH, 2005, 65 (12) :5205-5210
[8]   Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation [J].
Demetriou, M ;
Granovsky, M ;
Quaggin, S ;
Dennis, JW .
NATURE, 2001, 409 (6821) :733-739
[9]   Galectin-3:: An open-ended story [J].
Dumic, J ;
Dabelic, S ;
Flögel, M .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 1760 (04) :616-635
[10]   Evidence for subsites in the galectins involved in sugar binding at the nonreducing end of the central galactose of oligosaccharide ligands: sequence analysis, homology modeling and mutagenesis studies of hamster galectin-3 [J].
Henrick, K ;
Bawumia, S ;
Barboni, EAM ;
Mehul, B ;
Hughes, RC .
GLYCOBIOLOGY, 1998, 8 (01) :45-57