The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club

被引：41

作者：

Cavalier, E. ^{[1
]}

Bergmann, P. ^{[2
]}

Bruyere, O. ^{[3
]}

Delanaye, P. ^{[4
]}

Durnez, A. ^{[5
]}

Devogelaer, J. -P. ^{[5
]}

Ferrari, S. L. ^{[6
]}

Gielen, E. ^{[7
]}

Goemaere, S. ^{[8
]}

Kaufman, J. -M. ^{[8
,9
,10
]}

Toukap, A. Nzeusseu ^{[5
]}

Reginster, J. -Y. ^{[10
]}

Rousseau, A. -F. ^{[11
,12
]}

Rozenberg, S. ^{[13
]}

Scheen, A. J. ^{[14
]}

Body, J. -J. ^{[15
]}

机构：

[1] Univ Liege, CHU Liege, Dept Clin Chem, UnilabLg,CIRM, B-4000 Liege, Belgium

[2] Univ Libre Bruxelles, CHU Brugmann, Dept Radioisotopes, Brussels, Belgium

[3] Univ Liege, Dept Publ Hlth Epidemiol & Hlth Econ, B-4000 Liege, Belgium

[4] Univ Liege, CHU Liege, Dept Nephrol Dialysis Transplantat, B-4000 Liege, Belgium

[5] Catholic Univ Louvain, Clin Univ St Luc, Pole Pathol Rhumatismale, B-1200 Brussels, Belgium

[6] Hop Univ Geneve, Dept Bone Dis, Geneva, Switzerland

[7] Katholieke Univ Leuven, Dept Clin & Expt Med, Gerontol & Geriatr Sect, Leuven, Belgium

[8] Ghent Univ Hosp, Unit Osteoporosis & Metab Bone Dis, Ghent, Belgium

[9] Ghent Univ Hosp, Dept Endocrinol, Ghent, Belgium

[10] Ctr Acad Rech & Experimentat Sante SPRL CARES SPR, Liege, Belgium

[11] Univ Liege, CHU Liege, Burn Ctr, B-4000 Liege, Belgium

[12] Univ Liege, CHU Liege, Gen Intens Care Dept, B-4000 Liege, Belgium

[13] Univ Libre Bruxelles, Dept Gynaecol Obstet, Brussels, Belgium

[14] Univ Liege, CHU Liege, Div Diabet Nutr & Metab Disorders, B-4000 Liege, Belgium

[15] Univ Libre Bruxelles, CHU Brugmann, Dept Med, Brussels, Belgium

来源：

OSTEOPOROSIS INTERNATIONAL | 2016年 / 27卷 / 07期

关键词：

Biomarkers; Bone; Osteoporosis; RESISTANT ACID-PHOSPHATASE; MINERAL DENSITY; POSTMENOPAUSAL WOMEN; PROSTATE-CANCER; ELDERLY-MEN; VERTEBRAL FRACTURE; DIABETES-MELLITUS; DOUBLE-BLIND; BURN INJURY; SCLEROSTIN;

D O I：

10.1007/s00198-016-3561-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis.

引用

页码：2181 / 2195

页数：15

共 100 条

[1]

Abildgaard N, 2004, HAEMATOLOGICA, V89, P567

[2] Decreased serum sclerostin levels in patients with primary hyperparathyroidism: a cross-sectional and a longitudinal study [J].

Ardawi, M. -S. M. ;

Al-Sibiany, A. M. ;

Bakhsh, T. M. ;

Rouzi, A. A. ;

Qari, M. H. .

OSTEOPOROSIS INTERNATIONAL, 2012, 23 (06) :1789-1797

[3]

Baim S, 2009, J BONE MINER RES, V24, P561, DOI [10.1359/jbmr.090203, 10.1359/JBMR.090203]

[4]

Bauer DC, 2009, J BONE MINER RES, V24, P2032, DOI [10.1359/JBMR.090526, 10.1359/jbmr.090526]

[5] Bone turnover markers for osteoporotic status assessment? A systematic review of their diagnosis value at baseline in osteoporosis [J].

Biver, Emmanuel ;

Chopin, Florence ;

Coiffier, Guillaume ;

Brentano, Thomas Funck ;

Bouvard, Beatrice ;

Garnero, Patrick ;

Cortet, Bernard .

JOINT BONE SPINE, 2012, 79 (01) :20-25

[6] Early changes in biochemical markers of bone turnover and their relationship with bone mineral density changes after 24 months of treatment with teriparatide [J].

Blumsohn, A. ;

Marin, F. ;

Nickelsen, T. ;

Brixen, K. ;

Sigurdsson, G. ;

Gonzalez de la Vera, J. ;

Boonen, S. ;

Liu-Leage, S. ;

Barker, C. ;

Eastell, R. .

OSTEOPOROSIS INTERNATIONAL, 2011, 22 (06) :1935-1946

[7]

Body JJ, 2012, EXPERT REV ANTICANC, V12, P307, DOI [10.1586/ERA.11.204, 10.1586/era.11.204]

[8] Odanacatib, a Cathepsin-K Inhibitor for Osteoporosis: A Two-Year Study in Postmenopausal Women With Low Bone Density [J].

Bone, Henry G. ;

McClung, Michael R. ;

Roux, Christian ;

Recker, Robert R. ;

Eisman, John A. ;

Verbruggen, Nadia ;

Hustad, Carolyn M. ;

DaSilva, Carolyn ;

Santora, Arthur C. ;

Ince, B. Avery .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (05) :937-947

[9] Cathepsin K Preferentially Solubilizes Matured Bone Matrix [J].

Borel, Olivier ;

Gineyts, Evelyne ;

Bertholon, Cindy ;

Garnero, Patrick .

CALCIFIED TISSUE INTERNATIONAL, 2012, 91 (01) :32-39

[10] Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors [J].

Brown, JE ;

Cook, RJ ;

Major, P ;

Lipton, A ;

Saad, F ;

Smith, M ;

Lee, KA ;

Zheng, M ;

Hei, YJ ;

Coleman, RE .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (01) :59-69

← 1 2 3 4 5 6 7 8 9 10 →