Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

被引：228

作者：

Mertens, Jerome ^{[1
]}

Marchetto, Maria C. ^{[1
]}

Bardy, Cedric ^{[1
]}

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2016年 / 17卷 / 07期

关键词：

PLURIPOTENT STEM-CELLS; ADULT HUMAN FIBROBLASTS; FUNCTIONAL DOPAMINERGIC-NEURONS; PIONEER TRANSCRIPTION FACTORS; VERTEBRATE NERVOUS-SYSTEM; DIRECT LINEAGE CONVERSION; NEURAL STEM; MOTOR-NEURONS; DIRECTED DIFFERENTIATION; HUMAN ES;

D O I：

10.1038/nrn.2016.46

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The scarcity of live human brain cells for experimental access has for a long time limited our ability to study complex human neurological disorders and elucidate basic neuroscientific mechanisms. A decade ago, the development of methods to reprogramme somatic human cells into induced pluripotent stem cells enabled the in vitro generation of a wide range of neural cells from virtually any human individual. The growth of methods to generate more robust and defined neural cell types through reprogramming and direct conversion into induced neurons has led to the establishment of various human reprogramming-based neural disease models.

引用

页码：424 / 437

页数：14

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