Outcome of congenital heart defects - a population-based study

被引:93
作者
Meberg, A [1 ]
Otterstad, JE
Froland, G
Lindberg, H
Sorland, SJ
机构
[1] Vestfold Cty Cent Hosp, Dept Paediat, NO-3116 Tonsberg, Norway
[2] Vestfold Cty Cent Hosp, Dept Internal Med, Tonsberg, Norway
[3] Natl Hosp, Rikshosp, Dept Thorac & Cardiovasc Surg, Oslo, Norway
[4] Natl Hosp, Rikshosp, Dept Paediat Cardiol, Oslo, Norway
关键词
heart defects; outcome; persistent defect; spontaneous cure; surgery;
D O I
10.1080/080352500300002552
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In a population-based study including 35 218 infants born alive during the 15-y period 1982-96, 360 (1%) were diagnosed as having a congenital heart defect (CHD). At a follow-up 3-18 y after birth (median 9.5 y) 154 patients (42.8%) were spontaneously cured; of these, 142 (92.2%) had ventricular septal defects (VSDs). Forty-two patients (11.7%) died, 22 of these (52.4%) during the neonatal period (0-28 d after birth). A total of 119 patients (33.1%) underwent therapeutic procedures (surgery, catheter interventions), 24 (20.2%) of whom died. Of the 95 children surviving therapeutic procedures, 54 (56.8%) had their defects completely repaired, while 41 (43.2%) had residual defects or cardiac sequelae, often of minor importance. In 69 children (19.2%) with persistent non-operated defects; 43 (62.3%) had VSDs. A chromosomal disorder, syndrome or associated extracardiac malformation occurred in 72 children (20%). Conclusions: The study underlines the broad variety in severity of CHDs, with a high neonatal mortality rate as well as a high rate of spontaneous cure. It is estimated that 25% of infants born with a CHD will grow into adult age with persistent non-operated defects, residual defects or cardiac sequelae after therapeutic procedures.
引用
收藏
页码:1344 / 1351
页数:8
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