Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

被引：244
作者：
Owen, Bryn M. [1 ]
Mangelsdorf, David J. [1 ,3 ]
Kliewer, Steven A. [1 ,2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA
[3] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2015年 / 26卷 / 01期
基金：
美国国家卫生研究院;
关键词：
beta Klotho; brown adipose tissue; hypothalamus; sympathetic nervous system; arginine vasopressin; corticotropin-releasing factor; GROWTH-FACTOR; 21; BROWN ADIPOSE-TISSUE; CORTICOTROPIN-RELEASING FACTOR; INCREASES ENERGY-EXPENDITURE; IMPROVES GLUCOSE-TOLERANCE; ACTIVATED-RECEPTOR-GAMMA; INDUCED OBESE MICE; PPAR-ALPHA; INSULIN SENSITIVITY; BETA-KLOTHO;
D O I：
10.1016/j.tem.2014.10.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibroblast growth factors (FGFs) 15/19 and 21 belong to a subfamily of FGFs that function as hormones. Produced in response to specific nutritional cues, they act on overlapping sets of cell surface receptors composed of classic FGF receptors in complex with beta Klotho, and regulate metabolism and related processes during periods of fluctuating energy availability. Pharmacologically, both FGF15/19 and FGF21 cause weight loss and improve both insulin-sensitivity and lipid parameters in rodent and primate models of metabolic disease. Recently, FGF21 was shown to have similar effects in obese patients with type 2 diabetes. We discuss here emerging concepts in FGF15/19 and FGF21 tissue-specific actions and critically assess their putative role as candidate targets for treating metabolic disease.
引用
收藏
页码：22 / 29
页数：8
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