The antioxidant curcumin postpones ovarian aging in young and middle-aged mice

被引:48
作者
Azami, Saeideh Hasani [1 ]
Nazarian, Hamid [1 ]
Abdollahifar, Mohammad Amin [1 ]
Eini, Fatemeh [2 ]
Farsani, Mehdi Allahbakhshian [3 ,4 ]
Novin, Marefat Ghaffari [5 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Tehran 1985717443, Iran
[2] Hormozgan Univ Med Sci, Fertil & Infertil Res Ctr, Bandar Abbas, Iran
[3] Shahid Beheshti Univ Med Sci, Fac Allied Med Sci, Lab Haematol, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Fac Allied Med Sci, Blood Bank Dept, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Cellular & Mol Biol Res Ctr, Tehran 1985717443, Iran
关键词
in vitro fertilisation; ovarian reserve; oxidative stress; glutathione; IN-VITRO; FOLLICLES; METHOXYCHLOR; EXPRESSION; PROTECTS; OOCYTES; ATRESIA; FLUID; CELL;
D O I
10.1071/RD18472
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Reproductive senescence is accompanied by a reduced number and quality of ovarian follicles in response to the accumulation of free radicals and the process of apoptosis. Having selected mice as models, we examined the hypothesis that curcumin as an antioxidant and anti-inflammatory agent might prevent or retard ovarian aging. Female NMRI 21-day-old mice were divided into control, vehicle and curcumin groups. In the treatment group the mice received curcumin at 100 mg kg(-1) day(-1) intraperitoneally. After 6, 12 and 33 weeks several parameters were examined including ovarian reserve, oocyte quality, oxidative status, in vitro fertilisation and expression of ovulation-related (growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15)) and anti-aging-related (sirtuin 1 (SIRT-1) and SIRT-3) genes. Curcumin treatment up to 12 and 33 weeks resulted in increased ovarian volume and number of follicles and was associated with elevated anti-Mullerian hormone and oestrogen and diminished FSH serum levels. Furthermore, enhanced oocyte maturation, fertilisation and embryo development plus reduced oxidative stress were seen in the curcumin group. Also, the expression of GDF-9, BMP-15, SIRT-1 and SIRT-3 genes was increased in the curcumin group. Concerning gestational age, the findings of the study suggested that administration of curcumin could delay the process of oocyte aging in a mouse model.
引用
收藏
页码:292 / 303
页数:12
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