Genetic evidence for the involvement of lipid metabolism in Alzheimer's disease

被引：60

作者：

Jones, Lesley ^{[1
]}

Harold, Denise ^{[1
]}

Williams, Julie ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Cardiff CF14 4XN, S Glam, Wales

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2010年 / 1801卷 / 08期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; Neurodegeneration; Genetics; GWAS; Clusterin; PICALM; BIN1; GENOME-WIDE ASSOCIATION; AMYLOID PRECURSOR PROTEIN; EXTRACELLULAR CHAPERONE CLUSTERIN; SYNAPTIC VESICLE ENDOCYTOSIS; CENTRAL-NERVOUS-SYSTEM; APOLIPOPROTEIN-E; BETA-PEPTIDE; HUMAN PLASMA; CLUSTERIN/APOLIPOPROTEIN-J; MULTIFUNCTIONAL PROTEIN;

D O I：

10.1016/j.bbalip.2010.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and presents a great burden to sufferers and to society. The genetics of rare Mendelian forms of AD have been central to our understanding of AD pathogenesis for the past twenty years and now the genetics of the common form of the disease in the elderly is beginning to be unravelled by genome-wide association studies. Four new genes for common AD have been revealed in the past year, CLU, CR1, PICALM and BIN1. Their possible involvement in lipid metabolism and how that relates to AD is discussed here. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：754 / 761

页数：8

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