Copper-catalyzed gem-difluoromethylenation of C(sp2)-H bonds of alkenes

被引：19

作者：

Xu, Hui ^{[1
]}

Wang, Dejing ^{[1
]}

Chen, Yunrong ^{[1
]}

Wan, Wen ^{[1
]}

Deng, Hongmei ^{[2
]}

Ma, Kesen ^{[3
]}

Wu, Shaoxiong ^{[4
]}

Hao, Jian ^{[1
,5
]}

Jiang, Haizhen ^{[1
,5
]}

机构：

[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Lab Microstruct, Shanghai 200444, Peoples R China

[3] Univ Waterloo, Dept Biol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada

[4] Emory Univ, Emory NMR Res Ctr, 201 Dowman Dr, Atlanta, GA 30322 USA

[5] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 07期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; TERMINAL ALKENES; RECENT PROGRESS; TRIFLUOROMETHYLATION; DIFLUOROACETYLATION; FLUOROALKYLATION; INHIBITORS; CHEMISTRY; ARYLATION; FLUORINE;

D O I：

10.1039/c7qo00119c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed gem-difluoromethylenation of the C(sp(2))-H bonds of alkenes with high functional group tolerance has been developed. This protocol is the first to efficiently achieve gem-difluoromethylenation of C(sp(2))-H bonds of unactivated aliphatic terminal olefins and can be applied in a reaction cascade to achieve gem-difluoromethylenation/cyclization of alkenes.

引用

页码：1239 / 1243

页数：5

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