Alternaria Mycotoxins: An Overview of Toxicity, Metabolism, and Analysis in Food

被引：70

作者：

Chen, Anqi ^{[1
]}

Mao, Xin ^{[1
]}

Sun, Qinghui ^{[1
]}

Wei, Zixuan ^{[1
]}

Li, Juan ^{[2
]}

You, Yanli ^{[1
]}

Zhao, Jiqiang ^{[1
]}

Jiang, Guibin ^{[3
]}

Wu, Yongning ^{[4
]}

Wang, Liping ^{[5
]}

Li, Yanshen ^{[1
]}

机构：

[1] Yantai Univ, Coll Life Sci, Yantai 264005, Shandong, Peoples R China

[2] Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada

[3] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

[4] Chinese Acad Med Sci, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Res Unit 2019RU014, Beijing 100017, Peoples R China

[5] Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan 430070, Hubei, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2021年 / 69卷 / 28期

基金：

中国国家自然科学基金;

关键词：

Alternaria mycotoxins; food; toxicity; metabolic mechanism; analytical method; TANDEM MASS-SPECTROMETRY; UHPLC-MS/MS METHOD; MONOMETHYL ETHER; TENUAZONIC ACID; ALTERTOXIN-II; METHYL-ETHER; SPHINGOLIPID BIOSYNTHESIS; NATURAL OCCURRENCE; TOMATO PRODUCTS; DNA-DAMAGE;

D O I：

10.1021/acs.jafc.1c03007

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The genus Alternaria is widely distributed in the environment. Numerous species of the genus Alternaria can produce a variety of toxic secondary metabolites, called Alternaria mycotoxins. In this review, natural occurrence, toxicity, metabolism, and analytical methods are introduced. The contamination of these toxins in foodstuffs is ubiquitous, and most of these metabolites present genotoxic and cytotoxic effects. Moreover, Alternaria toxins are mainly hydroxylated to catechol metabolites and combined with sulfate and glucuronic acid in in vitro arrays. A more detailed summary of the metabolism of Alternaria toxins is presented in this work. To effectively detect and determine the mycotoxins in food, analytical methods with high sensitivity and good accuracy are also reviewed. This review will guide the formulation of maximum residue limit standards in the future, covering both toxicity and metabolic mechanism of Alternaria toxins.

引用

页码：7817 / 7830

页数：14

共 136 条

[1] Widespread Occurrence of Low Levels of Alternariol in Apple and Tomato Products, as Determined by Comparative Immunochemical Assessment using Monoclonal and Polyclonal Antibodies [J].