Cyclotriphosphazene-Based "Butterfly" Fluorescence Probe for Lysosome Targeting

被引：22
作者：
Liu, Pan [1 ]
Wang, Le [1 ]
Chen, Liang [2 ]
Su, Xiqi [1 ]
Shi, Xiangyang [2 ]
机构：
[1] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China
[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
来源：
BIOCONJUGATE CHEMISTRY | 2021年 / 32卷 / 06期
基金：
中国国家自然科学基金;
关键词：
CRYSTAL-STRUCTURE; QUANTUM DOTS; IDENTIFICATION; DEGRADATION; BEHAVIOR; CORE;
D O I：
10.1021/acs.bioconjchem.1c00160
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A cyclotriphosphazene-based "butterfly" fluorescence probe HCCP-MNI bearing two naphthalimide and morpholine units were developed for lysosome targeting. The synthesized HCCP-MNI exhibited stable fluorescence signals and was cytocompatible in the given concentration range. Co-localization experimental results showed that cells treated with the HCCP-MNI and a commercial dye (Lyso-Tracker Red DND-99) had overlapped fluorescence signals, demonstrating its targeting specificity to lysosomes. The developed HCCP-MNI may be used for cell tracking applications associated with the functionalities of lysosomes.
引用
收藏
页码：1117 / 1122
页数：6
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