The Contribution of Neuroimaging for the Study of Cognitive Deficits in Parkinson's Disease

被引：6
作者：
Monchi, Oury [1 ,2 ]
Martinu, Kristina [1 ,2 ]
Strafella, Antonio P. [3 ,4 ]
机构：
[1] Univ Montreal, Funct Neuroimaging Unit, Inst Univ Geriatrie Montreal, Montreal, PQ H3W 1W5, Canada
[2] Univ Montreal, Dept Radiol, Montreal, PQ H3W 1W5, Canada
[3] Univ Toronto, Toronto Western Res Inst & Hosp, UHN, Toronto, ON, Canada
[4] Univ Toronto, PET Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON, Canada
来源：
CLINICAL EEG AND NEUROSCIENCE | 2010年 / 41卷 / 02期
关键词：
Cognitive Deficits; Dopamine; Functional Magnetic Resonance Imaging; Parkinson's Disease; Positron Emission Tomography; PROGRESSIVE SUPRANUCLEAR PALSY; BASAL GANGLIA; DEFAULT MODE; DOPAMINERGIC MODULATION; SUBCORTICAL DEMENTIA; WORKING-MEMORY; TASK; DYSFUNCTION; MECHANISMS; HETEROGENEITY;
D O I：
10.1177/155005941004100206
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The last few years have seen an increase in the number of studies using functional Magnetic Resonance Imaging (fMRI) along with receptor imaging and regional cerebral blood flow Positron Emission Tomography (PET) to understand the neurobiological underpinnings of cognitive deficits in Parkinson's disease (PD). These studies have shown evidence that the nigrostriatal degeneration solely cannot account for these deficits and that involvement of other neural systems such as the mesocortical dopamine may also play an important role. In this article, we provide a review of neuroimaging results regarding the role of possible compensatory activity, L-Dopa medication, and difference in genotypes on the cognitive deficits observed in PD. Finally, some future avenues for research are proposed.
引用
收藏
页码：76 / 81
页数：6
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