Comparison between capillary electrophoresis and high-performance liquid chromatography for the stereoselective analysis of carvedilol in serum

被引：49

作者：

Clohs, L ^{[1
]}

McErlane, KM ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Div Pharmaceut Chem, Vancouver, BC V6T 1Z3, Canada

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 31卷 / 03期

关键词：

high-performance liquid chromatography; stereoselective analysis; carvedilol; capillary electrophoresis;

D O I：

10.1016/S0731-7085(02)00609-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic (HPLC) assay using a chiral stationary phase was developed and validated for the determination of carvedilol enantiomers in human serum and was compared with a previously developed capillary electrophoresis (CE) method. The CE and the HPLC assay were compared by analyzing a series of serum samples containing racemic carvedilol in different concentrations using the two methods. The concentrations obtained by the two assays were not found to be significantly different indicating that CE and HPLC are comparable in terms of reproducibility and precision for the stereoselective analysis of carvedilol in human serum. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：407 / 412

页数：6

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