Vaccinations in children with cancer

被引：40

作者：

Esposito, Susanna ^{[1
]}

Cecinati, Valerio ^{[2
]}

Brescia, Letizia ^{[2
]}

Principi, Nicola ^{[1
]}

机构：

[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Maternal & Pediat Sci, I-20122 Milan, Italy

[2] Univ Bari, Dept Dev Age Biomed, Bari, Italy

来源：

VACCINE | 2010年 / 28卷 / 19期

关键词：

Vaccination; Vaccines; Prevention; Cancer; Children; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEPATITIS-B-VIRUS; INFLUENZAE TYPE-B; ATTENUATED VARICELLA VACCINE; TRICOMPONENT ACELLULAR PERTUSSIS; ACUTE LYMPHOCYTIC-LEUKEMIA; IMMUNOCOMPROMISED CHILDREN; RECEIVING CHEMOTHERAPY; INTENSIVE CHEMOTHERAPY; HUMORAL IMMUNITY;

D O I：

10.1016/j.vaccine.2010.02.096

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Children with cancer may be immunocompromised as a result of their primary underlying disease and/or the use of prolonged and intensive chemotherapy administered with or without irradiation The damage to the immune system varies with the age of the patient, the type of cancer, and the intensity of the chemotherapy used to treat it This review analyses the data regarding the immunogenicity, efficacy, safety and tolerability of the vaccines usually recommended in the first years of life in order to help pediatricians choose the best immunisation programme against vaccine-preventable disease in children with cancer receiving standard-dose chemotherapy Areas for future research are highlighted because new data are required to be able to draw up evidence-based recommendations that will ensure adequate protection against infectious diseases in such high-risk children (C) 2010 Elsevier Ltd. All rights reserved

引用

页码：3278 / 3284

页数：7

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