Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/ β-Catenin Signaling Pathway

被引：17
作者：
Sun, Chunxiao [1 ]
Liu, Qianwen [1 ]
Shah, Mudassir [1 ]
Che, Qian [1 ]
Zhang, Guojian [1 ,2 ,3 ]
Zhu, Tianjiao [1 ]
Zhou, Jianfeng [1 ,2 ]
Rong, Xiaozhi [1 ,2 ]
Li, Dehai [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
[2] Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China
[3] Marine Biomed Res Inst Qingdao, Qingdao 266101, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 22期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
SMALL-MOLECULE INHIBITORS; CELLS; GROWTH; DIMERS; DUCLAUXIN; PORCUPINE; DISEASE; CANCER;
D O I：
10.1021/acs.orglett.2c01394
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Wnt/fi-catenin signaling pathway is an evolutionarily conserved signaling cascade involved in a broad range of biological roles. Dysregulation of the Wnt/fi-catenin pathway is implicated in congenital malformations and various kinds of cancers. We discovered a novel Wnt/ficatenin inhibitor, talaverrucin A (1), featuring an unprecedented 6/6/6/5/ 5/5/6 fused ring system, from an Antarctica sponge-derived fungus Talaromyces sp. HDN151403. Talaverrucin A exhibits inhibitory activity on the Wnt/fi-catenin pathway in both zebrafish embryos in vivo and cultured mammalian cells in vitro, providing a naturally inspired small molecule therapeutic lead to target the Wnt/fi-catenin pathway.
引用
收藏
页码：3993 / 3997
页数：5
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