Asymmetric total synthesis of (-)-perforanoid A

被引：12

作者：

Lv, Chao ^{[2
]}

Tu, Qian ^{[1
]}

Gong, Jianxian ^{[1
]}

Hao, Xiaojiang ^{[2
]}

Yang, Zhen ^{[1
]}

机构：

[1] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen 518055, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

来源：

TETRAHEDRON | 2017年 / 73卷 / 26期

基金：

美国国家科学基金会;

关键词：

(-)-Perforanoid A; Lemonoids; Asymmetric total synthesig; Rhodium catalyzed; Intramolecular Pauson-Khand; OSHIMA-UTIMOTO REACTION; PAUSON-KHAND REACTION; LIMONOIDS; INHIBITOR;

D O I：

10.1016/j.tet.2017.03.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric total synthesis of ( - )-perforanoid A, a novel limonoid isolated from the leaves of Harrisonia perforate, has been achieved. The key features of our total synthesis include the Rh-catalyzed intramolecular Pauson Khand reaction of an allene and an alkene, the Pd-catalyzed lactonization of an allylic alcohol with a vinyl ether, and the enantioselective alkenylation of 3-furaldehyde. (C) 2017 Published by Elsevier Ltd.

引用

页码：3612 / 3621

页数：10

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