Ultrasonication:: the way to achieve antimutagenic effect of carboxymethyl-chitin-glucan by oral administration

被引:28
作者
Chorvatovicová, D
Machová, E
Sandula, J
机构
[1] Slovak Acad Sci, Inst Expt Pharmacol, Bratislava 84216, Slovakia
[2] Slovak Acad Sci, Inst Chem, Bratislava, Slovakia
关键词
depolymerization; beta-glucan; ultrasonication; carboxymethyl-chitin-glucan; cyclophosphamide; mouse; micronucleus test; oral administration; antimutagenic effect;
D O I
10.1016/S1383-5718(97)00176-9
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Carboxymethyl-chitin-glucan (CMCG) isolated from Aspergillus niger was ultrasonicated to decrease its molecular weight. Ultrasonicated CMCG with molecular weight 0.19 x 10(-5) was administered either intraperitoneally or orally prior to cyclophosphamide (CP) injection and its effect on the frequency of micronuclei in polychromatic erythrocytes of mouse bone marrow was evaluated. Both ways of CMCG administration significantly decreased the clastogenic effect of CP. The protective effect of CMCG was concentration dependent, with a higher decrease achieved by 200 mg/kg than by 100 mg/kg b.wt. Ultrasonic depolymerization of high molecular CMCG resulted in its anticlastogenic effect against CP not only on intraperitoneal, but also on oral administration, achieved by decreasing its molecular weight. Ultrasonication proved to be an efficient way to obtain molecules of CMCG able to pass through the cell walls of the gastrointestinal tract. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:83 / 89
页数:7
相关论文
共 32 条
  • [1] Chobot V, 1995, Ceska Slov Farm, V44, P190
  • [2] EFFECT OF CARBOXYMETHYL-CHITIN-GLUCAN ON CYCLOPHOSPHAMIDE-INDUCED MUTAGENICITY
    CHORVATOVICOVA, D
    SANDULA, J
    [J]. MUTATION RESEARCH LETTERS, 1995, 346 (01): : 43 - 48
  • [3] Effect of ultrasonicated carboxymethylglucan on cyclophosphamide induced mutagenicity
    Chorvatovicova, D
    Machova, E
    Sandula, J
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY, 1996, 371 (1-2): : 115 - 120
  • [4] SUPPRESSING EFFECTS OF GLUCAN ON MICRONUCLEI INDUCED BY CYCLOPHOSPHAMIDE IN MICE
    CHORVATOVICOVA, D
    NAVAROVA, J
    [J]. MUTATION RESEARCH, 1992, 282 (03): : 147 - 150
  • [5] CHORVATOVICOVA D, 1991, Strahlentherapie und Onkologie, V167, P612
  • [6] SYNTHESIS AND ANTITUMOR-ACTIVITY OF SULFOALKYL DERIVATIVES OF CURDLAN AND LICHENAN
    DEMLEITNER, S
    KRAUS, J
    FRANZ, G
    [J]. CARBOHYDRATE RESEARCH, 1992, 226 (02) : 247 - 252
  • [7] FEOFILOVA EP, 1995, MICROBIOLOGY+, V64, P18
  • [8] STRUCTURAL INVESTIGATIONS OF GLUCANS FROM CULTURES OF GLOMERELLA-CINGULATA SPAULDING AND VONSCHRENCK
    GOMAA, K
    KRAUS, J
    FRANZ, G
    ROPER, H
    [J]. CARBOHYDRATE RESEARCH, 1991, 217 : 153 - 161
  • [9] GRAVE J, 1997, MUTAGENESIS, V12, P9
  • [10] CHEMICAL AND IMMUNOLOGICAL ANALYSIS OF THE ASPERGILLUS-FUMIGATUS CELL-WALL
    HEARN, VM
    SIETSMA, JH
    [J]. MICROBIOLOGY-UK, 1994, 140 : 789 - 795