Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways

被引：20

作者：

Siddiqui, Aisha ^{[1
]}

Akhtar, Sayeed ^{[3
]}

Shah, Zahoor ^{[2
]}

Othman, Iekhsan ^{[1
]}

Kumari, Yatinesh ^{[1
]}

机构：

[1] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Selangor 47500, Malaysia

[2] Univ Toledo, Dept Med & Biol Chem, 3000 Arlington Ave, Toledo, OH 43614 USA

[3] King Khalid Univ, Coll Pharm, Dept Clin Pharm, Abha 21974, Saudi Arabia

来源：

CURRENT NEUROPHARMACOLOGY | 2021年 / 19卷 / 06期

关键词：

Alzheimer's Diseases; 5-lipoxygenase; Neuro Inflammation; Neurodegeneration; Lipid Molecule; Arachidonic Acid; CEREBRAL ISCHEMIA-REPERFUSION; AMYLOID PRECURSOR PROTEIN; LEUKOTRIENE RECEPTOR 1; NECROSIS-FACTOR-ALPHA; ACTIVATING PROTEIN; NEUROFIBRILLARY TANGLES; OXIDATIVE STRESS; TAU PATHOLOGY; IN-VITRO; ABNORMAL PHOSPHORYLATION;

D O I：

10.2174/1570159X18666200924122732

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer's Disease ( AD) is one of them. However, much attention has been given to the link between tau and beta-amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via a different mechanism of inflammation. This review intends to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-LO).

引用

页码：885 / 895

页数：11

共 124 条

[21] 12-and 15-lipoxygenases in adipose tissue inflammation [J].

Cole, Banumathi K. ;

Lieb, David C. ;

Dobrian, Anca D. ;

Nadler, Jerry L. .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2013, 104 :84-92

[22] Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits [J].

Corser-Jensen, Chelsea E. ;

Goodell, Dayton J. ;

Freund, Ronald K. ;

Serbedzija, Predrag ;

Murphy, Robert C. ;

Farias, Santiago E. ;

Dell'Acqua, Mark L. ;

Frey, Lauren C. ;

Serkova, Natalie ;

Heidenreich, Kim A. .

EXPERIMENTAL NEUROLOGY, 2014, 256 :7-16

[23] Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study [J].

Cribbs, David H. ;

Berchtold, Nicole C. ;

Perreau, Victoria ;

Coleman, Paul D. ;

Rogers, Joseph ;

Tenner, Andrea J. ;

Cotman, Carl W. .

JOURNAL OF NEUROINFLAMMATION, 2012, 9

[24] Drug development in Alzheimer's disease: the path to 2025 [J].

Cummings, Jeffrey ;

Aisen, Paul S. ;

DuBois, Bruno ;

Froelich, Lutz ;

Jack, Clifford R., Jr. ;

Jones, Roy W. ;

Morris, John C. ;

Raskin, Joel ;

Dowsett, Sherie A. ;

Scheltens, Philip .

ALZHEIMERS RESEARCH & THERAPY, 2016, 8

[25] The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease [J].

Czapski, Grzegorz A. ;

Czubowicz, Kinga ;

Strosznajder, Joanna B. ;

Strosznajder, Robert P. .

NEUROCHEMICAL RESEARCH, 2016, 41 (1-2) :243-257

[26] Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology [J].

Das Sarma, Jayasri .

JOURNAL OF NEUROVIROLOGY, 2014, 20 (02) :122-136

[27] Involvement of 5-Lipoxygenase in Alzheimer's Disease: A Role for DNA Methylation [J].

Di Francesco, Andrea ;

Arosio, Beatrice ;

Gussago, Cristina ;

Dainese, Enrico ;

Mari, Daniela ;

D'Addario, Claudio ;

Maccarrone, Mauro .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 37 (01) :3-8

[28] Cysteinyl-leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes [J].

Di Gennaro, A ;

Carnini, C ;

Buccellati, C ;

Ballerio, R ;

Zarini, S ;

Fumagalli, F ;

Viappiani, S ;

Librizzi, L ;

Hernandez, A ;

Murphy, RC ;

Constantin, G ;

de Curtis, M ;

Folco, G ;

Sala, A .

FASEB JOURNAL, 2004, 18 (03) :842-+

[29] ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance [J].

Elias, Ivet ;

Ferre, Tura ;

Vila, Laia ;

Munoz, Sergio ;

Casellas, Alba ;

Garcia, Miquel ;

Molas, Maria ;

Agudo, Judith ;

Roca, Carles ;

Ruberte, Jesus ;

Bosch, Fatima ;

Franckhauser, Sylvie .

DIABETES, 2016, 65 (08) :2139-2150

[30] Microglia: Key Elements in Neural Development, Plasticity, and Pathology [J].

Eyo, Ukpong B. ;

Dailey, Michael E. .

JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2013, 8 (03) :494-509

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