Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways

被引：18
作者：
Siddiqui, Aisha [1 ]
Akhtar, Sayeed [3 ]
Shah, Zahoor [2 ]
Othman, Iekhsan [1 ]
Kumari, Yatinesh [1 ]
机构：
[1] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Selangor 47500, Malaysia
[2] Univ Toledo, Dept Med & Biol Chem, 3000 Arlington Ave, Toledo, OH 43614 USA
[3] King Khalid Univ, Coll Pharm, Dept Clin Pharm, Abha 21974, Saudi Arabia
来源：
CURRENT NEUROPHARMACOLOGY | 2021年 / 19卷 / 06期
关键词：
Alzheimer's Diseases; 5-lipoxygenase; Neuro Inflammation; Neurodegeneration; Lipid Molecule; Arachidonic Acid; CEREBRAL ISCHEMIA-REPERFUSION; AMYLOID PRECURSOR PROTEIN; LEUKOTRIENE RECEPTOR 1; NECROSIS-FACTOR-ALPHA; ACTIVATING PROTEIN; NEUROFIBRILLARY TANGLES; OXIDATIVE STRESS; TAU PATHOLOGY; IN-VITRO; ABNORMAL PHOSPHORYLATION;
D O I：
10.2174/1570159X18666200924122732
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer's Disease ( AD) is one of them. However, much attention has been given to the link between tau and beta-amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via a different mechanism of inflammation. This review intends to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-LO).
引用
收藏
页码：885 / 895
页数：11
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