Intermolecular cyclization of N-methylanilines and maleimides to tetrahydroquinolines via K2S2O8 promoted C(sp3)-H activation

被引：27

作者：

Yadav, Arvind K. ^{[1
]}

Yadav, Lai Dhar S. ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Green Synth Lab, Allahabad 211002, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 13期

关键词：

Cyclization; N-Methylanilines; Maleimides; Heterocycles; Radical reactions; Tetrahydroquinolines; H BOND ACTIVATION; ARYLBORONIC ACIDS; AEROBIC OXYSULFONYLATION; CATALYZED ARYLATION; COUPLING REACTIONS; TERTIARY ANILINES; COPPER; FUNCTIONALIZATION; DERIVATIVES; PALLADIUM;

D O I：

10.1016/j.tetlet.2016.02.078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free, novel and convenient way for the direct cyclization of N-methylanilines with maleimides to tetrahydroquinolines via C(sp(3))-H activation is reported. The protocol utilizes inexpensive and easy to handle K2S2O8 as a radical surrogate and involves sequential formation of C(sp(3))-C(sp(2)) and C(sp(2))-C(sp(2)) bonds in a one-pot procedure at room temperature. The method affords excellent yield of tricyclic compounds incorporating biologically important tetrahydroquinoline core. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1489 / 1491

页数：3

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