The central cannabinoid receptor type-2 (CB2) and chronic pain

被引：29
作者：
Shang, Yuchao [1 ,2 ]
Tang, Yuying [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp 2, Dept Anesthesiol, Chengdu, Peoples R China
[2] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2017年 / 127卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Cannabinoid; CB2; pain; analgesia; clinical; RANDOMIZED CONTROLLED-TRIAL; CHRONIC NEUROPATHIC PAIN; INCREASES INTRACELLULAR CALCIUM; ACTIVATED PROTEIN-KINASE; SPINAL DORSAL-HORN; MULTIPLE-SCLEROSIS; GLIAL ACTIVATION; NERVE INJURY; PHARMACOLOGICAL CHARACTERIZATION; IN-VITRO;
D O I：
10.1080/00207454.2016.1257992
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cannabinoid receptor type-2 (CB2, CB2 receptor or CB2-R) mediates analgesia via two mechanisms. CB2 receptors contained in peripheral immune tissue mediate analgesia by altering cytokine profiles, and thus have little adverse effects on central nervous systems (CNSs). CB2 is also expressed in the neurons and glial cells of the CNS. This neuronal expression may also contribute to pain attenuation. The CB2 receptor has been proposed as a potential target in treating chronic pain of several etiologies.
引用
收藏
页码：812 / 823
页数：12
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