The central cannabinoid receptor type-2 (CB2) and chronic pain

被引：29
|
作者：
Shang, Yuchao [1 ,2 ]
Tang, Yuying [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp 2, Dept Anesthesiol, Chengdu, Peoples R China
[2] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2017年 / 127卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Cannabinoid; CB2; pain; analgesia; clinical; RANDOMIZED CONTROLLED-TRIAL; CHRONIC NEUROPATHIC PAIN; INCREASES INTRACELLULAR CALCIUM; ACTIVATED PROTEIN-KINASE; SPINAL DORSAL-HORN; MULTIPLE-SCLEROSIS; GLIAL ACTIVATION; NERVE INJURY; PHARMACOLOGICAL CHARACTERIZATION; IN-VITRO;
D O I：
10.1080/00207454.2016.1257992
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cannabinoid receptor type-2 (CB2, CB2 receptor or CB2-R) mediates analgesia via two mechanisms. CB2 receptors contained in peripheral immune tissue mediate analgesia by altering cytokine profiles, and thus have little adverse effects on central nervous systems (CNSs). CB2 is also expressed in the neurons and glial cells of the CNS. This neuronal expression may also contribute to pain attenuation. The CB2 receptor has been proposed as a potential target in treating chronic pain of several etiologies.
引用
收藏
页码：812 / 823
页数：12
相关论文
共 50 条
  • [1] Recent Advances on Type-2 Cannabinoid (CB2) Receptor Agonists and their Therapeutic Potential
    Gasperi, Valeria
    Guzzo, Tatiana
    Topai, Alessandra
    Gambacorta, Nicola
    Ciriaco, Fulvio
    Nicolotti, Orazio
    Maccarrone, Mauro
    CURRENT MEDICINAL CHEMISTRY, 2023, 30 (12) : 1420 - 1457
  • [2] The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists
    Whiteside, G. T.
    Lee, G. P.
    Valenzano, K. J.
    CURRENT MEDICINAL CHEMISTRY, 2007, 14 (08) : 917 - 936
  • [3] Cannabinoid Receptor CB2 Structure and CB2/Gi Signaling Mechanisms
    Xing, Changrui
    Zhang, Cheng
    Xie, Xiang-Qun
    FASEB JOURNAL, 2019, 33
  • [4] The CB2 cannabinoid receptor as a therapeutic target in the central nervous system
    Cabanero, David
    Martin-Garcia, Elena
    Maldonado, Rafael
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2021, 25 (08) : 659 - 676
  • [5] Review -: New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors
    Gertsch, Juerg
    Raduner, Stefan
    Altmann, Karl-Heinz
    JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2006, 26 (5-6) : 709 - 730
  • [6] CB2: a cannabinoid receptor with an identity crisis
    Atwood, Brady K.
    Mackie, Ken
    BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (03) : 467 - 479
  • [7] Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists
    Han, Sangdon
    Thatte, Jayant
    Buzard, Daniel J.
    Jones, Robert M.
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (21) : 8224 - 8256
  • [8] CB2 cannabinoid receptor mediation of antinociception
    Ibrahim, Mohab M.
    Rude, Megan L.
    Stagg, Nicola J.
    Mata, Heriberto P.
    Lai, Josephine
    Vanderah, Todd W.
    Porreca, Frank
    Buckley, Nancy E.
    Makriyannis, Alexandros
    Malan, T. Philip, Jr.
    PAIN, 2006, 122 (1-2) : 36 - 42
  • [9] Brain Cannabinoid CB2 Receptor in Schizophrenia
    Ishiguro, Hiroki
    Horiuchi, Yasue
    Ishikawa, Maya
    Koga, Minori
    Imai, Keiko
    Suzuki, Yoshimi
    Morikawa, Miyuki
    Inada, Toshiya
    Watanabe, Yuichiro
    Takahashi, Makoto
    Someya, Toshiyuki
    Ujike, Hiroshi
    Iwata, Nakao
    Ozaki, Norio
    Onaivi, Emmanuel S.
    Kunugi, Hiroshi
    Sasaki, Tsukasa
    Itokawa, Masanari
    Arai, Makoto
    Niizato, Kazuhiro
    Iritani, Shyuji
    Naka, Izumi
    Ohashi, Jun
    Kakita, Akiyoshi
    Takahashi, Hitoshi
    Nawa, Hiroyuki
    Arinami, Tadao
    BIOLOGICAL PSYCHIATRY, 2010, 67 (10) : 974 - 982
  • [10] Targeting the CB2 cannabinoid receptor in osteoporosis
    Bab, Itai
    Ofek, Orr
    EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2011, 6 (02) : 135 - 138
12345