High prevalence of serum metabolic alterations in primary Sjogren's syndrome:: Influence on clinical and immunological expression

被引:1
作者
Ramos-Casals, Manuel
Brito-Zeron, Pilar
Siso, Antoni
Vargas, Alfonso
Ros, Emili
Bove, Albert
Belenguer, Rafael
Plaza, Joan
Benavent, Jaume
Font, Josep
机构
[1] Hosp Clin Barcelona, IDIBAPS, E-08036 Barcelona, Spain
[2] Univ Barcelona, Sch Med, Dept Med, E-08007 Barcelona, Spain
[3] Univ Barcelona, Sch Med, Dept Autoimmune Dis, E-08007 Barcelona, Spain
[4] Univ Barcelona, Sch Med, Lipid Unit, E-08007 Barcelona, Spain
[5] Ctr Assistencia Primaria ABS Les Corts, Barcelona, Spain
关键词
hypercholesterolemia; hypertriglyceridemia; diabetes mellitus; Sjogren's syndrome; serum metabolic alterations;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To analyze the prevalence and clinical significance of associated metabolic alterations [dyslipidemia, diabetes mellitus (DM), and hyperuricemia] in a large series of unselected patients with primary Sjogren's syndrome (SS). Methods. We analyzed 254 consecutive patients with primary SS who had a complete analytical followup study for at least 5 consecutive years. The control group consisted of 254 age and sex-matched patients without systemic autoimmune diseases consecutively followed during the same period in a primary care center. Results. In comparison with controls, patients with primary SS showed a higher frequency of dyslipidemia (47% vs 33%; p = 0.002), DM (28% vs 18%; p = 0.006), and hyperuricemia (9% vs 4%; p = 0.007). The mean age at SS diagnosis was 10 years greater in patients with DM (p < 0.001) and hyperuricemia (p = 0.009). Hypercholesterolemia was associated with a lower frequency of immunological markers such as anti-Ro/SSA antibodies (p = 0.001), anti-La/SSB antibodies (p = 0.005), low C3 (p = 0.047), and low C4 levels (p = 0.030), while hypertriglyceridemia and DM were associated with a higher prevalence of extraglandular features, especially renal, liver, and vasculitic involvement. A higher prevalence of DM was found in patients treated with corticosteroids (40% vs 19%; p = 0.001). Conclusion. Patients with primary SS showed a higher prevalence of associated dyslipidemia, DM, and hyperuricemia in comparison with an age and sex-matched control group. Metabolic alterations were associated with a differentiated pattern of clinical and immunological SS expression, but not with SS-related therapies (except for the higher frequency of DM observed in patients treated with corticosteroids).
引用
收藏
页码:754 / 761
页数:8
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