Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications

被引：136
作者：
Carreira, Ana Claudia [1 ,2 ]
Alves, Gutemberg Gomes [3 ]
Zambuzzi, William Fernando [4 ]
Sogayar, Mari Cleide [1 ,2 ]
Granjeiro, Jose Mauro [5 ,6 ]
机构：
[1] Univ Sao Paulo, Dept Biochem, Inst Chem, BR-05508000 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Dept Clin Med, NUCEL NETCEM Cell & Mol Therapy Ctr, BR-05508000 Sao Paulo, Brazil
[3] Univ Fed Fluminense, Inst Biol, Dept Cell & Mol Biol, Niteroi, RJ, Brazil
[4] Univ Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil
[5] Natl Inst Metrol Qual & Technol, Bioengn Div, Duque De Caxias, RJ, Brazil
[6] Univ Fed Fluminense, Sch Dent, Dept Dent Mat, Niteroi, RJ, Brazil
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 561卷
关键词：
Bone Morphogenetic Proteins; Osteogenesis inducing proteins; Peptide growth factors; Bone repair; Extracellular matrix; Tissue engineering; MESENCHYMAL STEM-CELLS; ACTIVITY IN-VITRO; GROWTH-FACTORS; OSTEOBLAST DIFFERENTIATION; SIGNALING PATHWAYS; BETA SUPERFAMILY; TGF-BETA; BMP; EXPRESSION; RECOMBINANT;
D O I：
10.1016/j.abb.2014.07.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-beta superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process. (C) 2014 Published by Elsevier Inc.
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收藏
页码：64 / 73
页数：10
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