Oxidative stress and NO generation in the rat pancreatitis induced by pancreatic duct ligation

被引：19

作者：

Buchwalow, Igor ^{[1
]}

Schnekenburger, Juergen ^{[2
]}

Atiakshin, Dmitri ^{[3
]}

Samoilova, Vera ^{[1
]}

Wolf, Eduard ^{[1
]}

Boecker, Werner ^{[1
]}

Tiemann, Katharina ^{[1
]}

机构：

[1] Inst Hematopathol, D-22547 Hamburg, Germany

[2] Westfalische Wilhelms Univ, Biomed Technol Ctr, D-48149 Munster, Germany

[3] Burdenko Voronezh State Med Univ, Res Inst Expt Biol & Med, Voronezh, Russia

来源：

ACTA HISTOCHEMICA | 2017年 / 119卷 / 03期

关键词：

Acute pancreatitis; Nitric oxide; Oxidative stress; Pancreatic duct ligation; NITRIC-OXIDE SYNTHASE; BETA-CELLS; EXPRESSION;

D O I：

10.1016/j.acthis.2017.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The interaction between nitric oxide (NO) and superoxides is critical in the development of an acute pancreatitis. Previously, we reported that the expression of superoxides and of the NO-generating enzyme (NO synthase, NOS) was up-regulated in the human pancreatitis, especially within the exocrine compartment indicating an exceptional susceptibility of the exocrine parenchyma to oxidative stress. The aim of the present study was to compare the regulation of NO signalling pathways in the human pancreatitis and in an animal model of an acute pancreatitis induced by pancreatic duct ligation (PDL) in rats. In the PDL-induced rat pancreatitis, we revealed a similar pattern of oxidative stress and NOS up-regulation in acinar and in ductal compartments, like in the human pancreatitis. This demonstrates that the PDL-induced rat pancreatitis is a proper model for further studies of acute pancreatitis development in humans. (C) 2017 Elsevier GmbH. All rights reserved.

引用

页码：252 / 256

页数：5

共 27 条

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