Recrudescent Campylobacter jejuni Infection in an Immunocompetent Adult following Experimental Infection with a Well-Characterized Organism

被引:25
作者
Baqar, Shahida [2 ,3 ]
Tribble, David R. [2 ,3 ]
Carmolli, Marya [1 ]
Sadigh, Katrin [1 ]
Poly, Frederic [2 ]
Porter, Chad [2 ]
Larsson, Catherine J. [1 ]
Pierce, Kristen K. [1 ]
Guerry, Patricia [2 ]
Darsley, Michael [4 ]
Kirkpatrick, Beth [1 ]
机构
[1] Univ Vermont, Coll Med, Infect Dis Unit, Vaccine Testing Ctr, Burlington, VT 05405 USA
[2] USN, Med Res Ctr, Silver Spring, MD USA
[3] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA
[4] ACE Biosci, Hillerod, Denmark
关键词
LINKED-IMMUNOSORBENT-ASSAY; ANTIBODY-RESPONSE; ENTERITIS; CHILDREN; DIARRHEA; EXERCISE; CIPROFLOXACIN; EPIDEMIOLOGY; IMMUNOLOGY; IMMUNITY;
D O I
10.1128/CVI.00252-09
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The recrudescence of infection with Campylobacter jejuni after appropriate antibiotic treatment has not been previously reported in an immunocompetent adult. We present the complete clinical, microbiologic, and immunologic evaluation of a closely monitored healthy male with recrudescent C. jejuni infection occurring in the absence of immunodeficiency following experimental infection with a well-characterized strain. After antibiotic treatment, the initial infection was clinically cleared and microbiologically undetectable. Subsequently, two episodes of recrudescence occurred, with no change in in vitro antibiotic sensitivity being detected. The immune responses of the individual were compared to those of other participants in the experimental infection study: innate immune responses, including fecal cytokines and C-reactive protein, were intact; however, measures of Campylobacter-specific adaptive immune responses were absent, including serum antibodies, antibody-secreting cells, and in vitro gamma interferon responses. No primary or secondary immunodeficiency was identified. Recrudescent Campylobacter infections after treatment may be more common than has previously been appreciated. This work adds to our understanding of the human immune response to natural Campylobacter infection and reiterates the importance of pathogen-specific adaptive immune responses to this globally important pathogen.
引用
收藏
页码:80 / 86
页数:7
相关论文
共 47 条
[1]   CAMPYLOBACTER ENTERITIS IN IMMUNE-DEFICIENT PATIENTS [J].
AHNEN, DJ ;
BROWN, WR .
ANNALS OF INTERNAL MEDICINE, 1982, 96 (02) :187-188
[2]   Molecular and spatial epidemiology of cryptosporidiosis in children in a semiurban community in South India [J].
Ajjampur, Sitara Swarna Rao ;
Gladstone, Beryl Primrose ;
Selvapandian, David ;
Muliyil, Jaya Prakash ;
Ward, Honorine ;
Kang, Gagandeep .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (03) :915-920
[3]   Campylobacter-stimulated INT407 cells produce dissociated cytokine profiles [J].
Al-Salloom, FS ;
Mahmeed, AA ;
Ismaeel, A ;
Botta, GA ;
Bakhiet, M .
JOURNAL OF INFECTION, 2003, 47 (03) :217-224
[4]   Association between Campylobacter infection and Guillain-Barre syndrome [J].
Allos, BM .
JOURNAL OF INFECTIOUS DISEASES, 1997, 176 :S125-S128
[5]  
[Anonymous], 2005, MMWR-MORBID MORTAL W, V54, P352
[6]   SAFETY AND IMMUNOGENICITY OF A PROTOTYPE ORAL WHOLE-CELL KILLED CAMPYLOBACTER VACCINE ADMINISTERED WITH A MUCOSAL ADJUVANT IN NONHUMAN-PRIMATES [J].
BAQAR, S ;
BOURGEOIS, AL ;
SCHULTHEISS, PJ ;
WALKER, RI ;
ROLLINS, DM ;
HABERBERGER, RL ;
PAVLOVSKIS, OR .
VACCINE, 1995, 13 (01) :22-28
[7]   Campylobacter jejuni enteritis [J].
Baqar, S ;
Rice, B ;
Lee, LF ;
Bourgeois, AL ;
El Din, AN ;
Tribble, DR ;
Heresi, GP ;
Mourad, AS ;
Murphy, JR .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (06) :901-905
[8]   EXPERIMENTAL CAMPYLOBACTER-JEJUNI INFECTION IN HUMANS [J].
BLACK, RE ;
LEVINE, MM ;
CLEMENTS, ML ;
HUGHES, TP ;
BLASER, MJ .
JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (03) :472-479
[9]   HUMAN-SERUM ANTIBODY-RESPONSE TO CAMPYLOBACTER-JEJUNI INFECTION AS MEASURED IN AN ENZYME-LINKED IMMUNOSORBENT-ASSAY [J].
BLASER, MJ ;
DUNCAN, DJ .
INFECTION AND IMMUNITY, 1984, 44 (02) :292-298
[10]   CAMPYLOBACTER ENTERITIS IN THE UNITED-STATES - A MULTICENTER STUDY [J].
BLASER, MJ ;
WELLS, JG ;
FELDMAN, RA ;
POLLARD, RA ;
ALLEN, JR .
ANNALS OF INTERNAL MEDICINE, 1983, 98 (03) :360-365