Newborn screening: Current status

被引:30
作者
Arn, Pamela H. [1 ]
机构
[1] Nemours Childrens Clin, Jacksonville, FL USA
关键词
D O I
10.1377/hlthaff.26.2.559
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Newborn screening, which represents one of the major advances in child health of the past century, has been carried out in all fifty U.S. states since the 1970s. Newborn screening programs are state-run, and decisions are left to the individual states regarding the conditions to be screened for, the mechanism for confirmatory testing, follow-up care, and financing of the programs. Laboratory advances in tandem mass spectrometry make it possible to screen newborns for many rare inborn errors of metabolism. This raises many policy issues including screening's cost-effectiveness, ethics, quality, and oversight.
引用
收藏
页码:559 / 566
页数:8
相关论文
共 25 条
[1]   Making policy when the evidence is in dispute [J].
Atkins, D ;
Siegel, J ;
Slutsky, J .
HEALTH AFFAIRS, 2005, 24 (01) :102-113
[2]   Newborn screening technology: Proceed with caution [J].
Botkin, JR ;
Clayton, EW ;
Fost, NC ;
Burke, W ;
Murray, TH ;
Baily, MA ;
Wilfond, B ;
Berg, A ;
Ross, LF .
PEDIATRICS, 2006, 117 (05) :1793-1799
[3]   Comprehensive cost-utility analysis of newborn screening strategies [J].
Carroll, AE ;
Downs, SM .
PEDIATRICS, 2006, 117 (05) :S287-S295
[4]   The natural history of medium-chain acyl CoA dehydrogenase deficiency in the Netherlands: Clinical presentation and outcome [J].
Derks, Terry G. J. ;
Reijngoud, Dirk-Jan ;
Waterham, Hans R. ;
Gerver, Willem-Jan M. ;
van den Berg, Maarten P. ;
Sauer, Pieter J. J. ;
Smit, G. Peter A. .
JOURNAL OF PEDIATRICS, 2006, 148 (05) :665-670
[5]   Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders [J].
Gelb, Michael H. ;
Turecek, Frantisek ;
Scott, C. Ron ;
Chamoles, Nestor A. .
JOURNAL OF INHERITED METABOLIC DISEASE, 2006, 29 (2-3) :397-404
[6]   We need expanded newborn screening [J].
Howell, RR .
PEDIATRICS, 2006, 117 (05) :1800-1805
[7]   Financing state newborn screening programs: Sources and uses of funds [J].
Johnson, K ;
Lloyd-Puryear, MA ;
Mann, MY ;
Ramos, LR ;
Therrell, BL .
PEDIATRICS, 2006, 117 (05) :S270-S279
[8]   Newborn screening for metabolic disorders [J].
Marsden, Deborah ;
Larson, Cecilia ;
Levy, Harvey L. .
JOURNAL OF PEDIATRICS, 2006, 148 (05) :577-584
[9]   THE ANALYSIS OF DIAGNOSTIC MARKERS OF GENETIC-DISORDERS IN HUMAN BLOOD AND URINE USING TANDEM MASS-SPECTROMETRY WITH LIQUID SECONDARY ION MASS-SPECTROMETRY [J].
MILLINGTON, DS ;
KODO, N ;
TERADA, N ;
ROE, D ;
CHACE, DH .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 1991, 111 :211-228
[10]   TANDEM MASS-SPECTROMETRY - A NEW METHOD FOR ACYLCARNITINE PROFILING WITH POTENTIAL FOR NEONATAL SCREENING FOR INBORN-ERRORS OF METABOLISM [J].
MILLINGTON, DS ;
KODO, N ;
NORWOOD, DL ;
ROE, CR .
JOURNAL OF INHERITED METABOLIC DISEASE, 1990, 13 (03) :321-324