Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group

被引：43
作者：
Yeoh, Allen Eng-Juh [1 ]
Lu, Yi [1 ]
Chan, Jason Yong-Sheng [1 ]
Chan, Yiong Huak [2 ]
Ariffin, Hany [3 ]
Kham, Shirley Kow-Yin [1 ]
Quah, Thuan Chong [1 ]
机构：
[1] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Div Haematol & Oncol, Dept Paediat, Singapore, Singapore
[2] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Biostat Unit, Singapore, Singapore
[3] Univ Malaya, Dept Paediat, Div Haematol & Oncol, Kuala Lumpur, Malaysia
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 03期
关键词：
Childhood ALL; Genetic epidemiology; Polymorphism; Gender effect; NQO1; Folate metabolism; Malay; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; REDUCED FOLATE CARRIER; NAD(P)H-QUINONE OXIDOREDUCTASE; QUINONE OXIDOREDUCTASE; TOTAL HOMOCYSTEINE; COMMON MUTATION; RISK-FACTOR; POLYMORPHISMS; ASSOCIATION; CANCER;
D O I：
10.1016/j.leukres.2009.07.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：276 / 283
页数：8
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