20 Years of Mre11 Biology: No End in Sight

被引：97
作者：
Paull, Tanya T. [1 ,2 ,3 ]
机构：
[1] Univ Texas Austin, Howard Hughes Med Inst, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA
[3] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA
来源：
MOLECULAR CELL | 2018年 / 71卷 / 03期
关键词：
DOUBLE-STRAND-BREAK; COLLAPSED REPLICATION FORKS; DEPENDENT DNA-BINDING; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; NUCLEASE ACTIVITIES; HOMOLOGOUS RECOMBINATION; MRE11-DEPENDENT DEGRADATION; MRE11-RAD50-NBS1; COMPLEX; MEIOTIC RECOMBINATION;
D O I：
10.1016/j.molcel.2018.06.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Mre11 nuclease has been the subject of intensive investigation for the past 20 years because of the central role that Mre11/Rad50 complexes play in genome maintenance. The last two decades of work on this complex has led to a much deeper understanding of the structure, biochemical activities, and regulation of Mre11/Rad50 complexes from archaea, bacteria, and eukaryotic cells. This review will discuss some of the important findings over recent years that have illuminated roles for the Mre11 nuclease in these different contexts as well as the insights from structural biology that have helped us to understand its mechanisms of action.
引用
收藏
页码：419 / 427
页数：9
相关论文
共 104 条
  • [1] AJIMURA M, 1993, GENETICS, V133, P51
  • [2] Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection
    Anand, Roopesh
    Ranjha, Lepakshi
    Cannavo, Elda
    Cejka, Petr
    [J]. MOLECULAR CELL, 2016, 64 (05) : 940 - 950
  • [3] Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast
    Arora, Sucheta
    Deshpande, Rajashree A.
    Budd, Martin
    Campbell, Judy
    Revere, America
    Zhang, Xiaoming
    Schmidt, Kristina H.
    Paull, Tanya T.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2017, 37 (24)
  • [4] DNA end resection is needed for the repair of complex lesions in G1-phase human cells
    Averbeck, Nicole B.
    Ringel, Oliver
    Herrlitz, Maren
    Jakob, Burkhard
    Durante, Marco
    Taucher-Scholz, Gisela
    [J]. CELL CYCLE, 2014, 13 (16) : 2509 - 2516
  • [5] Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1
    Barton, Olivia
    Naumann, Steffen C.
    Diemer-Biehs, Ronja
    Kuenzel, Julia
    Steinlage, Monika
    Conrad, Sandro
    Makharashvili, Nodar
    Wang, Jiadong
    Feng, Lin
    Lopez, Bernard S.
    Paull, Tanya T.
    Chen, Junjie
    Jeggo, Penny A.
    Loebrich, Markus
    [J]. JOURNAL OF CELL BIOLOGY, 2014, 206 (07) : 877 - 894
  • [6] Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation
    Belen Vallerga, Maria
    Mansilla, Sabrina F.
    Belen Federico, Maria
    Bertolin, Agustina P.
    Gottifredi, Vanesa
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (48) : E6624 - E6633
  • [7] Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential
    Bennardo, Nicole
    Gunn, Amanda
    Cheng, Anita
    Hasty, Paul
    Stark, Jeremy M.
    [J]. PLOS GENETICS, 2009, 5 (10)
  • [8] Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
    Bennardo, Nicole
    Cheng, Anita
    Huang, Nick
    Stark, Jeremy M.
    [J]. PLOS GENETICS, 2008, 4 (06)
  • [9] DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination
    Biehs, Ronja
    Steinlage, Monika
    Barton, Olivia
    Juhasz, Szilvia
    Kuenzel, Julia
    Spies, Julian
    Shibata, Atsushi
    Jeggo, Penny A.
    Loebrich, Markus
    [J]. MOLECULAR CELL, 2017, 65 (04) : 671 - +
  • [10] Bressan DA, 1998, GENETICS, V150, P591
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