Late-stage [18F]fluorination: new solutions to old problems

被引：251

作者：

Brooks, Allen F. ^{[1
]}

Topczewski, Joseph J. ^{[2
]}

Ichiishi, Naoko ^{[2
]}

Sanford, Melanie S. ^{[2
]}

Scott, Peter J. H. ^{[1
,3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Interdept Program Med Chem, Ann Arbor, MI 48109 USA

来源：

CHEMICAL SCIENCE | 2014年 / 5卷 / 12期

关键词：

OXIDATIVE FLUORINATION; IODONIUM YLIDES; PET; F-18; SALTS; RADIOPHARMACEUTICALS; RADIOSYNTHESIS; ARENES; ARYL; C-11;

D O I：

10.1039/c4sc02099e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The last 2-3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These collaborations have led to the development of many new strategies for the late-stage introduction of fluorine-18 into complex bioactive molecules. In this perspective we highlight recent developments and key milestones since 2011.

引用

页码：4545 / 4553

页数：9

共 56 条

[1] Molecular imaging with PET [J].

Ametamey, Simon M. ;

Honer, Michael ;

Schubiger, Pius August .

CHEMICAL REVIEWS, 2008, 108 (05) :1501-1516

[2] Regio- and stereoretentive synthesis of branched, linear (E)- and (Z)-allyl fluorides from allyl carbonates under Ir-catalysis [J].

Benedetto, Elena ;

Tredwell, Matthew ;

Hollingworth, Charlotte ;

Khotavivattana, Tanatorn ;

Brown, John M. ;

Gouverneur, Veronique .

CHEMICAL SCIENCE, 2013, 4 (01) :89-96

[3] CYCLIC SULFATES - USEFUL SUBSTRATES FOR SELECTIVE NUCLEOPHILIC-SUBSTITUTION [J].

BERRIDGE, MS ;

FRANCESCHINI, MP ;

ROSENFELD, E ;

TEWSON, TJ .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (04) :1211-1217

[4]

Bietendorf Jim, 2004, J Nucl Med Technol, V32, P33

[5]

Brandt JR, 2014, CHEM SCI, V5, P169, DOI [10.1039/C3SC52367E, 10.1039/c3sc52367e]

[6] Chemistry with [18F]fluoride ion [J].

Cai, Lisheng ;

Lu, Shuiyu ;

Pike, Victor W. .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (17) :2853-2873

[7] Iodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F] fluorophenoxy)-phenylmethyl) piperidine NET and SERT ligands [J].

Cardinale, Jens ;

Ermert, Johannes ;

Humpert, Sven ;

Coenen, Heinz H. .

RSC ADVANCES, 2014, 4 (33) :17293-17299

[8]

CHAKRABORTY PK, 1991, APPL RADIAT ISOTOPES, V42, P673

[9] Rapid and Efficient Radiosyntheses of meta-Substituted [18F]Fluoroarenes from [18F]Fluoride Ion and Diaryliodonium Tosylates within a Microreactor [J].

Chun, Joong-Hyun ;

Lu, Shuiyu ;

Pike, Victor W. .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (23) :4439-4447

[10] Radiosyntheses using Fluorine-18: The Art and Science of Late Stage Fluorination [J].

Cole, Erin L. ;

Stewart, Megan N. ;

Littich, Ryan ;

Hoareau, Raphael ;

Scott, Peter J. H. .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2014, 14 (07) :875-900

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