Late-stage [18F]fluorination: new solutions to old problems

被引：246
作者：
Brooks, Allen F. [1 ]
Topczewski, Joseph J. [2 ]
Ichiishi, Naoko [2 ]
Sanford, Melanie S. [2 ]
Scott, Peter J. H. [1 ,3 ]
机构：
[1] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Interdept Program Med Chem, Ann Arbor, MI 48109 USA
来源：
CHEMICAL SCIENCE | 2014年 / 5卷 / 12期
关键词：
OXIDATIVE FLUORINATION; IODONIUM YLIDES; PET; F-18; SALTS; RADIOPHARMACEUTICALS; RADIOSYNTHESIS; ARENES; ARYL; C-11;
D O I：
10.1039/c4sc02099e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The last 2-3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These collaborations have led to the development of many new strategies for the late-stage introduction of fluorine-18 into complex bioactive molecules. In this perspective we highlight recent developments and key milestones since 2011.
引用
收藏
页码：4545 / 4553
页数：9
相关论文
共 56 条
  • [1] Molecular imaging with PET
    Ametamey, Simon M.
    Honer, Michael
    Schubiger, Pius August
    [J]. CHEMICAL REVIEWS, 2008, 108 (05) : 1501 - 1516
  • [2] Regio- and stereoretentive synthesis of branched, linear (E)- and (Z)-allyl fluorides from allyl carbonates under Ir-catalysis
    Benedetto, Elena
    Tredwell, Matthew
    Hollingworth, Charlotte
    Khotavivattana, Tanatorn
    Brown, John M.
    Gouverneur, Veronique
    [J]. CHEMICAL SCIENCE, 2013, 4 (01) : 89 - 96
  • [3] CYCLIC SULFATES - USEFUL SUBSTRATES FOR SELECTIVE NUCLEOPHILIC-SUBSTITUTION
    BERRIDGE, MS
    FRANCESCHINI, MP
    ROSENFELD, E
    TEWSON, TJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (04) : 1211 - 1217
  • [4] Bietendorf Jim, 2004, J Nucl Med Technol, V32, P33
  • [5] Brandt JR, 2014, CHEM SCI, V5, P169, DOI [10.1039/C3SC52367E, 10.1039/c3sc52367e]
  • [6] Chemistry with [18F]fluoride ion
    Cai, Lisheng
    Lu, Shuiyu
    Pike, Victor W.
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (17) : 2853 - 2873
  • [7] Iodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F] fluorophenoxy)-phenylmethyl) piperidine NET and SERT ligands
    Cardinale, Jens
    Ermert, Johannes
    Humpert, Sven
    Coenen, Heinz H.
    [J]. RSC ADVANCES, 2014, 4 (33): : 17293 - 17299
  • [8] CHAKRABORTY PK, 1991, APPL RADIAT ISOTOPES, V42, P673
  • [9] Rapid and Efficient Radiosyntheses of meta-Substituted [18F]Fluoroarenes from [18F]Fluoride Ion and Diaryliodonium Tosylates within a Microreactor
    Chun, Joong-Hyun
    Lu, Shuiyu
    Pike, Victor W.
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (23) : 4439 - 4447
  • [10] Radiosyntheses using Fluorine-18: The Art and Science of Late Stage Fluorination
    Cole, Erin L.
    Stewart, Megan N.
    Littich, Ryan
    Hoareau, Raphael
    Scott, Peter J. H.
    [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2014, 14 (07) : 875 - 900
123456