Hydroxylation of a vitamin D A-ring fragment

被引：0

作者：

Hamon, C ^{[1
]}

Soilan-Rodriguez, JD ^{[1
]}

Kalchhauser, H ^{[1
]}

Reischl, W ^{[1
]}

机构：

[1] Univ Vienna, Dept Organ Chem, A-1090 Vienna, Austria

来源：

MONATSHEFTE FUR CHEMIE | 1997年 / 128卷 / 12期

关键词：

vitamin D; vitamin D A-ring fragment; C-1; hydroxylation; Hg(OOCCF3)(2);

D O I：

10.1007/BF00807263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

When the benzoate of (S)-(Z)-2-(5-(tert-butyldimethylsiloxy)-2-methylencyclohexyliden)-ethanol (5) is treated with 2.5 equivalents of Hg(OOCCF3)(2) in dry THF, a smooth and selective allylic hydroxylation occurs. The C-1 functionalized vitamin D A-ring synthon 6 is isolated in 65 to 70% yield in a single step.

引用

页码：1297 / 1300

页数：4

共 22 条

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