Dynamical complexity and temporal plasticity in pancreatic β-cells

被引：25
作者：
Bertram, R [1 ]
Sherman, A
机构：
[1] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA
[2] NIDDKD, Mathat Res Branch, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF BIOSCIENCES | 2000年 / 25卷 / 02期
关键词：
bursting; coupled oscillators; mathematical model;
D O I：
10.1007/BF03404915
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We discuss some of the biological and mathematical issues involved in understanding and modelling the bursting electrical activity in pancreatic beta-cells. These issues include single-cell versus islet behaviour, parameter heterogeneity, channel noise, the effects of hormones, neurotransmitters, and ions, and multiple slow biophysical processes. Some of the key experimental and modelling studies are described, and some of the major open questions are discussed.
引用
收藏
页码：197 / 209
页数：13
相关论文
共 59 条
[1]   GLUCOSE INDUCES CLOSURE OF SINGLE POTASSIUM CHANNELS IN ISOLATED RAT PANCREATIC BETA-CELLS [J].
ASHCROFT, FM ;
HARRISON, DE ;
ASHCROFT, SJH .
NATURE, 1984, 312 (5993) :446-448
[2]   ELECTROPHYSIOLOGY OF THE PANCREATIC BETA-CELL [J].
ASHCROFT, FM ;
RORSMAN, P .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1989, 54 (02) :87-143
[3]   PROPERTIES OF THE CA-ACTIVATED K+CHANNEL IN PANCREATIC BETA-CELLS [J].
ATWATER, I ;
ROSARIO, L ;
ROJAS, E .
CELL CALCIUM, 1983, 4 (5-6) :451-461
[4]  
Atwater I., 1980, Biochemistry and Biophysics of the Pancreatic fl-Cell, P100
[5]  
BEIGELMAN PM, 1977, J PHYSIOLOGY PARIS, V73, P201
[6]   TOPOLOGICAL AND PHENOMENOLOGICAL CLASSIFICATION OF BURSTING OSCILLATIONS [J].
BERTRAM, R ;
BUTTE, MJ ;
KIEMEL, T ;
SHERMAN, A .
BULLETIN OF MATHEMATICAL BIOLOGY, 1995, 57 (03) :413-439
[7]   A ROLE FOR CALCIUM RELEASE-ACTIVATED CURRENT (CRAC) IN CHOLINERGIC MODULATION OF ELECTRICAL-ACTIVITY IN PANCREATIC BETA-CELLS [J].
BERTRAM, R ;
SMOLEN, P ;
SHERMAN, A ;
MEARS, D ;
ATWATER, I ;
MARTIN, F ;
SORIA, B .
BIOPHYSICAL JOURNAL, 1995, 68 (06) :2323-2332
[8]  
BERTRAM R, 2000, BIOPHYS J
[9]  
BORDIN S, 1995, J MEMBRANE BIOL, V148, P177
[10]   ROLE OF SINGLE-CHANNEL STOCHASTIC NOISE ON BURSTING CLUSTERS OF PANCREATIC BETA-CELLS [J].
CHAY, TR ;
KANG, HS .
BIOPHYSICAL JOURNAL, 1988, 54 (03) :427-435
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