Endocrine Disruptors and Human Health

被引：32

作者：

Latini, G. ^{[1
]}

Knipp, G. ^{[2
]}

Mantovani, A. ^{[3
]}

Marcovecchio, M. L. ^{[4
]}

Chiarelli, F. ^{[4
]}

Soder, O. ^{[5
,6
]}

机构：

[1] Osped A Perrino, Div Neonatol, I-72100 Brindisi, Italy

[2] Purdue Univ, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA

[3] Ist Super Sanita, Food & Vet Toxicol Unit, Dept Vet Publ Hlth & Food Safety, I-00161 Rome, Italy

[4] Univ G dAnnunzio, Dept Pediat, Chieti, Italy

[5] Karolinska Inst, Dept Womens & Childrens Hlth, Paediat Endocrinol Unit, S-17176 Stockholm, Sweden

[6] Univ Hosp, S-17176 Stockholm, Sweden

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 09期

关键词：

Endocrine-disruptors; environment; endocrine system; phthalates; pregnancy; neonate; fetal; TESTICULAR DYSGENESIS SYNDROME; FATTY-ACID HOMEOSTASIS; THYROID-HORMONE LEVELS; BUTYL PHTHALATE DBP; IN-UTERO EXPOSURE; BISPHENOL-A; DI(2-ETHYLHEXYL) PHTHALATE; POLYCHLORINATED-BIPHENYLS; ENVIRONMENTAL ESTROGENS; INTERNAL EXPOSURE;

D O I：

10.2174/138955710791608271

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Endocrine-disrupting chemicals (EDCs) are a group of diversely natural compounds or synthetic chemicals that can interfere with the programming of normal endocrine-signalling pathways during pre- and neonatal life, thus leading to adverse consequences later in life. In addition, early life exposure to EDCs may alter gene expression and consequently transmit these effects to future generations.

引用

页码：846 / 855

页数：10

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