Synthesis of 1-(2,3-dimethyl-1-phenyl-pyrazolone-5-yl-4)-2-mercapto-1′,5-cycloalkane-spiro[1,3]thiazolo[3,4-b]-1,2,4-triazole derivatives

被引：16

作者：

Shaker, RM ^{[1
]}

机构：

[1] Menia Univ, Fac Sci, Dept Chem, El Minia, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2003年 / 178卷 / 05期

关键词：

spiro thiazolidin-4-ones; synthesis; thiazolo-[3,4-b]-1,2,4-triazoles; thiosemicarbazones;

D O I：

10.1080/10426500307854

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New thiosemicarbazone derivatives 3a-c, obtained by the condensation of 4-(2,3-dimethyl-1-phenyl-pyrazolone-5-yl-4)-thiosemicarbazide (1) with cycloalkanones 2a-c, on reaction with mercaptoacetic acid (4) yields the corresponding spiro thiazolidin-4-ones 5a-c. Compound 5 undergo intramolecular heterocyclization to the corresponding 1-(2,3-ditnethyl-l-phenyl-pyrazolone-5-yl-4)-2-mercapto-1',5-cycloalkane-spiro[1,3]thiazolo[3,4-b]-1,2,4-triazoles 6a-c with NaOH. [GRAPHICS]

引用

页码：1175 / 1182

页数：8

共 20 条

[1] Synthesis of spiro[2H-indole-2,1′-1H-isoindole]-3,3′-diones, spiro[1H-isobenzofuran-1,2′-2H-indole]-3,3′-diones and spiro[benzofuran-2,1′-isobenzofuran]-3,3′-diones via transannular reactions of eight membered ring intermediates [J].