Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy

被引：22

作者：

Huizar, Jose F. ^{[1
,2
]}

Tan, Alex Y. ^{[1
,2
]}

Kaszala, Karoly ^{[1
,2
]}

Ellenbogen, Kenneth A. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Pauley Heart Ctr, 1201 Broad Rock Blvd Ste 4A-100, Richmond, VA 23249 USA

[2] Hunter Holmes McGuire Vet Affairs Med Ctr, Richmond, VA USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2021年 / 66卷

关键词：

Premature ventricular contraction; Premature atrial contraction; Heart rate irregularity; LV dyssynchrony; Eccentric hypertrophy; CATHETER ABLATION; RADIOFREQUENCY ABLATION; DILATED CARDIOMYOPATHY; ANTIARRHYTHMIC-DRUGS; COUPLING INTERVAL; HEART-FAILURE; FREQUENT; COMPLEXES; DYSFUNCTION; ECTOPY;

D O I：

10.1016/j.pcad.2021.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-todate comprehensive review of these pre-clinical and clinical studies. Published by Elsevier Inc.

引用

页码：17 / 27

页数：11

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