Bismuth Sulfide Nanorods as a Precision Nanomedicine for in Vivo Multimodal Imaging-Guided Photothermal Therapy of Tumor

被引：517

作者：

Liu, Jing ^{[1
,2
]}

Zheng, Xiaopeng ^{[1
,2
,3
]}

Yan, Liang ^{[1
,2
]}

Zhou, Liangjun ^{[1
,2
,3
]}

Tian, Gan ^{[1
,2
]}

Yin, Wenyan ^{[1
,2
]}

Wang, Liming ^{[1
,2
]}

Liu, Ying ^{[1
,2
]}

Hu, Zhongbo ^{[3
]}

Gu, Zhanjun ^{[1
,2
]}

Chen, Chunying ^{[1
,2
]}

Zhao, Yuliang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China

[2] Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China

[3] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing, Peoples R China

来源：

ACS NANO | 2015年 / 9卷 / 01期

关键词：

Bi2S3; nanorods; thin bandgap semiconductor; multispectral optoacoustic tomography; X-ray computed tomography; photothermal therapy; UP-CONVERSION NANOPARTICLES; LARGE-SCALE SYNTHESIS; THERANOSTIC PLATFORM; DRUG-DELIVERY; CANCER-CELLS; METASTASIS INHIBITION; TANTALUM OXIDE; CONTRAST AGENT; GOLD NANORODS; TOMOGRAPHY;

D O I：

10.1021/nn506137n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we present a precision cancer nanomedicine based on Bi2S3 nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi2S3 NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as satellite and precision targeted weapon for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi2S3 NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.

引用

页码：696 / 707

页数：12

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